Department VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania; Center of Molecular Research in Nephrology and Vascular Disease, Faculty of the University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania; County Emergency Hospital "Pius Brinzeu", L. Rebreanu, Nr. 156, 300723 Timisoara, Romania.
Center of Molecular Research in Nephrology and Vascular Disease, Faculty of the University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania; County Emergency Hospital "Pius Brinzeu", L. Rebreanu, Nr. 156, 300723 Timisoara, Romania.
Life Sci. 2024 Nov 1;356:123044. doi: 10.1016/j.lfs.2024.123044. Epub 2024 Sep 4.
During the COVID-19 pandemic sex-related differences concerning the spectrum of cardiovascular complications have been observed in the acute infection, and during recovery. This study aims to emphasize sex-related disparities regarding left ventricular systolic function (LVSF), right ventricular function (RVF), diastolic dysfunction (DD), and pericardial pathologies during the post-COVID-19 syndrome.
274 patients with post-acute COVID-19 syndrome, 127 men and 147 women, aged under 55, were evaluated within 90 days after the acute illness and followed at 3 and 6 months.
Based on detailed transthoracic echocardiography (TTE), we identified significantly more frequently (p˂0.001) altered LVSF in men, while in women impaired RVF, and DD were significantly more common (p˂0.001). Pericardial impairment did not seem to be influenced by gender. The TTE parameters characterizing these patterns were correlated with the severity of the initial infection and the time elapsed since and alleviated in time. The multivariate regression analysis confirmed these sex-related associations and their impact on patients' functional status.
Male patients had a higher tendency to develop altered LVSF, while female subjects had more frequently impaired RVF and DD. These abnormalities alleviated in time and exerted a significant influence on patients' functional status.
在 COVID-19 大流行期间，急性感染和康复期间观察到与心血管并发症谱相关的性别差异。本研究旨在强调 COVID-19 后综合征期间左心室收缩功能（LVSF）、右心室功能（RVF）、舒张功能障碍（DD）和心包病变的性别差异。
对 274 名急性 COVID-19 后综合征患者（年龄均小于 55 岁）进行评估，其中男性 127 例，女性 147 例，于急性疾病后 90 天内进行评估，并在 3 个月和 6 个月时进行随访。
根据详细的经胸超声心动图（TTE）检查，我们发现男性的 LVSF 改变更为常见（p<0.001），而女性的 RVF 受损和 DD 更为常见（p<0.001）。心包损害似乎不受性别影响。这些模式的 TTE 参数与初始感染的严重程度以及自感染以来的时间和缓解程度相关。多变量回归分析证实了这些与性别相关的关联及其对患者功能状态的影响。
男性患者更倾向于发生 LVSF 改变，而女性患者更常出现 RVF 和 DD 受损。这些异常随着时间的推移而缓解，并对患者的功能状态产生显著影响。
