Tudoran Cristina, Bende Renata, Bende Felix, Giurgi-Oncu Catalina, Enache Alexandra, Dumache Raluca, Tudoran Mariana
Department VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.
Center of Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.
Biology (Basel). 2023 Feb 26;12(3):370. doi: 10.3390/biology12030370.
(1) Background: Throughout the COVID-19 pandemic, it became obvious that individuals suffering with obesity, diabetes mellitus (T2DM), and metabolic syndrome (MS) frequently developed persisting cardiovascular complications, which were partially able to explain the onset of the long-COVID-19 syndrome. (2) Methods: Our aim was to document, by transthoracic echocardiography (TTE), the presence of cardiac alterations in 112 patients suffering from post-acute COVID-19 syndrome and T2DM, MS, and/or obesity, in comparison to 91 individuals without metabolic dysfunctions (MD); (3) Results: in patients with MD, TTE borderline/abnormal left (LVF) and/or right ventricular function (RVF), alongside diastolic dysfunction (DD), were more frequently evidenced, when compared to controls ( ˂ 0.001). Statistically significant associations between TTE parameters and the number of factors defining MS, the triglyceride-glucose (TyG) index, the severity of the SARS-CoV-2 infection, and the number of persisting symptoms ( ˂ 0.001) were noted. Significant predictive values for the initial C-reactive protein and TyG index levels, both for the initial and the 6-month follow-up levels of these TTE abnormalities ( ˂ 0.001), were highlighted by means of a multivariate regression analysis. (4) Conclusions: in diabetic patients with MS and/or obesity with comorbid post-acute COVID-19 syndrome, a comprehensive TTE delineates various cardiovascular alterations, when compared with controls. After 6 months, LVF and RVF appeared to normalize, however, the DD-although somewhat improved-did persist in approximately a quarter of patients with MD, possibly due to chronic myocardial changes.
(1) 背景：在整个新冠疫情期间，显而易见的是，肥胖、2型糖尿病（T2DM）和代谢综合征（MS）患者经常出现持续的心血管并发症，这在一定程度上能够解释长新冠综合征的发病情况。(2) 方法：我们的目的是通过经胸超声心动图（TTE）记录112例患有急性后新冠综合征以及T2DM、MS和/或肥胖的患者的心脏改变情况，并与91例无代谢功能障碍（MD）的个体进行比较；(3) 结果：与对照组相比，MD患者中TTE显示左心室功能（LVF）和/或右心室功能（RVF）处于临界/异常状态以及舒张功能障碍（DD）的情况更为常见（<0.001）。TTE参数与定义MS的因素数量、甘油三酯-葡萄糖（TyG）指数、严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的严重程度以及持续症状的数量之间存在统计学显著关联（<0.001）。通过多变量回归分析突出显示了初始C反应蛋白和TyG指数水平对这些TTE异常的初始水平和6个月随访水平均具有显著预测价值（<0.001）。(4) 结论：与对照组相比，在患有MS和/或肥胖且合并急性后新冠综合征的糖尿病患者中，全面的TTE可描绘出各种心血管改变情况。6个月后，LVF和RVF似乎恢复正常，然而，DD虽然有所改善，但仍在大约四分之一的MD患者中持续存在，这可能是由于慢性心肌改变所致。
