Fritz Réka, Kiricsi Ágnes, Csanády Miklós, Fritz Péter
Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary.
Department of Oto-Rhino-Laryngology and Head-and Neck Surgery, University of Szeged, Tisza Lajos Krt. 111, Szeged, 6725, Hungary.
Eur Arch Otorhinolaryngol. 2025 Jan;282(1):387-394. doi: 10.1007/s00405-024-08902-8. Epub 2024 Sep 6.
In recent decades studies have examined body weight changes following tonsillectomy. In nutrition science, the focus has shifted from body mass index to body composition analysis. However, no studies have explored body composition changes post-tonsillectomy. In oncology and digestive surgeries, the potential benefits of branched-chain amino acids (BCAAs) have been investigated; however, their effects on pharyngeal surgery remain unknown. Therefore, the aim of the present study was to investigate the body composition changes after tonsillectomy and to explore the potential benefits of branched-chain amino acids.
This prospective interventional controlled study enrolled 48 patients who were randomly assigned to a control group (CG) and an experimental group (EG). These groups were further divided into active and inactive subgroups on the basis of their activity levels. The EG consumed 2 × 4 mg of BCAA daily. Body composition was measured using bioimpedance (InBody 270) on the day of surgery and again on days 7 and 21 postoperatively.
Both groups experienced similar weight loss; however, significant differences in body composition emerged. The CG showed significant muscle mass loss (from 30,29 to 28,51 kg), whereas active EG members maintained muscle mass (from 35,33 to 35,40 kg); inactive EG members increased muscle mass (from 26,70 to 27,56 kg) and reduced body fat percentage (from 31.94% to 29.87%). The general health status (InBody score) remained stable or improved in the EG (from 75,13 to 75,96); however, it decreased in the CG (from 75,42 to 72,67).
The negative effects of tonsillectomy on body composition are mitigated by BCAA supplementation.
近几十年来，已有研究对扁桃体切除术后的体重变化进行了检测。在营养科学领域，关注点已从体重指数转向身体成分分析。然而，尚无研究探讨扁桃体切除术后的身体成分变化。在肿瘤学和消化外科手术中，已对支链氨基酸（BCAAs）的潜在益处进行了研究；然而，其对咽部手术的影响仍不明确。因此，本研究的目的是调查扁桃体切除术后的身体成分变化，并探索支链氨基酸的潜在益处。
这项前瞻性干预对照研究纳入了48例患者，这些患者被随机分为对照组（CG）和实验组（EG）。根据活动水平，这些组进一步分为活跃和不活跃亚组。实验组每天摄入2×4毫克的支链氨基酸。在手术当天以及术后第7天和第21天，使用生物电阻抗法（InBody 270）测量身体成分。
两组体重均有相似程度的下降；然而，身体成分出现了显著差异。对照组肌肉质量显著下降（从30.29千克降至28.51千克），而活跃的实验组成员维持了肌肉质量（从35.33千克增至35.40千克）；不活跃的实验组成员肌肉质量增加（从26.70千克增至27.56千克）且体脂百分比降低（从31.94%降至29.87%）。实验组的总体健康状况（InBody评分）保持稳定或有所改善（从75.13升至75.96）；然而，对照组的该评分下降（从75.42降至72.67）。
补充支链氨基酸可减轻扁桃体切除术对身体成分的负面影响。
