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镰状窦脑内恶性脑膜瘤:病例报告及文献复习。

Malignant meningioma of the falx cerebri in a child: case report and literature review.

机构信息

Sanbo Brain Hospital Capital Medical University, Haidian District, No. 50, Yikesong Road, XiangshanBeijing, China.

Department of Neurosurgery, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, Jiangsu, China.

出版信息

Childs Nerv Syst. 2024 Dec;40(12):4295-4300. doi: 10.1007/s00381-024-06600-8. Epub 2024 Sep 6.

Abstract

Meningiomas are common intracranial tumors in adults but rare in pediatric cases, with malignant histological features being even less frequent. Primary pediatric malignant meningioma of the falx cerebri has not been previously reported in the literature. We present a case of a malignant meningioma of the falx cerebri in a child who was admitted to the hospital following head trauma, presenting with mental impairment and limb weakness. CT examination revealed a right parietal epidural hematoma and a large intracranial lesion. The patient underwent drainage of the intracranial hematoma and a two-frontal craniotomy with tumor resection under microscopy. Histopathological analysis confirmed malignant meningioma, and genetic testing identified a YAP1-MAML2 gene fusion. There is no consensus on the clinical, imaging, and pathological features of pediatric meningiomas. In this paper, we discuss the clinical features, diagnostic and treatment protocols, and pathological characteristics of this case, along with a review of the relevant literature.

摘要

脑膜瘤是成人常见的颅内肿瘤,但在儿科病例中罕见,具有恶性组织学特征的脑膜瘤更为罕见。镰状窦脑内原发性小儿恶性脑膜瘤在文献中尚未有报道。我们报告了一例镰状窦脑内恶性脑膜瘤患儿,该患儿因头部外伤后入院,表现为精神障碍和肢体无力。CT 检查显示右侧顶骨硬膜外血肿和颅内大病变。患者接受了颅内血肿引流和显微镜下的双额开颅肿瘤切除术。组织病理学分析证实为恶性脑膜瘤,基因检测发现 YAP1-MAML2 基因融合。儿科脑膜瘤的临床、影像学和病理学特征尚无共识。本文讨论了该病例的临床特征、诊断和治疗方案以及病理特征,并复习了相关文献。

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