The Francis Crick Institute, London, United Kingdom.
Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
EMBO Mol Med. 2024 Oct;16(10):2290-2298. doi: 10.1038/s44321-024-00135-w. Epub 2024 Sep 6.
The aryl hydrocarbon receptor is a ligand dependent transcription factor which functions as an environmental sensor. Originally discovered as the sensor for man made pollutants such as 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) it has recently gained prominence as an important mediator for environmental triggers via the diet or microbiota which influences many physiological functions in different cell types and tissues across the body. Notably AHR activity contributes to prevent excessive inflammation following tissue damage in barrier organs such as skin, lung or gut which has received wide attention in the past decade. In this review we will focus on emerging common AHR functions across cell types and tissues and discuss ongoing issues that confound the understanding of AHR physiology. Furthermore, we will discuss the need for deeper molecular understanding of the functional activity of AHR in different contexts with respect to development of potential therapeutic applications.
芳香烃受体是一种配体依赖性转录因子，作为环境传感器发挥作用。最初被发现是作为人造污染物（如 2,3,7,8-四氯二苯并对二恶英（TCDD））的传感器，它最近作为通过饮食或微生物组影响体内不同细胞类型和组织的许多生理功能的环境触发因素的重要介质而受到关注。值得注意的是，AHR 活性有助于防止屏障器官（如皮肤、肺或肠道）组织损伤后的过度炎症，这在过去十年中受到了广泛关注。在这篇综述中，我们将重点介绍跨细胞类型和组织的 AHR 常见功能，并讨论当前混淆 AHR 生理学理解的问题。此外，我们将讨论在不同背景下对 AHR 功能的分子理解的必要性，以期开发潜在的治疗应用。
