Department of Cardiology, The Eighth Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, No. 3025 Shennan Middle Road, Shenzhen, Guangdong, People's Republic of China.
Guangdong Innovative Engineering and Technology Research Center for Assisted Circulation, Sun Yat-sen University, Shenzhen, 518033, People's Republic of China.
BMC Public Health. 2024 Sep 6;24(1):2431. doi: 10.1186/s12889-024-19862-3.
Atherogenic index of plasma (AIP) index is an important marker of insulin resistance and a significant risk factor for cardiovascular disease. Abdominal aortic calcification (AAC) is significantly associated with subclinical atherosclerotic disease. However, there are no studies that have examined the relationship between AIP index and AAC, so we investigated the potential association between them in the general population.
This was a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES, 2013-2014). The association of AIP with AAC was estimated by multivariable regression analysis.
After adjusting for confounders, the odds of extensive AAC doubled per unit increase in the AIP index (OR = 2.00, 95% CI: 1.05, 3.83; P = 0.035). The multivariable OR and 95% CI of the highest AIP index tertile compared with the lowest tertile was significantly different. (OR = 1.73, 95% CI: 1.05, 2.83; P = 0.031). The subgroup analyses indicated that the association was consistent irrespective of age, sex, hypertension, diabetes, smoking status, eGFR and hypercholesteremia.
The AIP index was independently associated with the presence of extensive AAC in the study population. Further studies are required to confirm this relationship.
血浆致动脉粥样硬化指数（AIP）是胰岛素抵抗的一个重要标志物，也是心血管疾病的一个重要危险因素。腹主动脉钙化（AAC）与亚临床动脉粥样硬化疾病显著相关。然而，目前尚无研究探讨 AIP 指数与 AAC 之间的关系，因此我们在一般人群中研究了它们之间的潜在关联。
这是一项横断面研究，使用了国家健康和营养检查调查（NHANES，2013-2014 年）的数据。采用多变量回归分析估计 AIP 与 AAC 之间的关联。
在校正混杂因素后，AIP 指数每增加一个单位，广泛 AAC 的发生几率增加一倍（OR=2.00，95%CI：1.05，3.83；P=0.035）。与最低三分位相比，最高三分位 AIP 指数的多变量 OR 和 95%CI 显著不同（OR=1.73，95%CI：1.05，2.83；P=0.031）。亚组分析表明，这种关联在年龄、性别、高血压、糖尿病、吸烟状况、eGFR 和高胆固醇血症等方面是一致的。
在研究人群中，AIP 指数与广泛 AAC 的存在独立相关。需要进一步的研究来证实这种关系。
