Department of Cardiosurgery Intensive Care Unit, Ningbo Medical Centre Li Huili Hospital, Ningbo, China.
Front Endocrinol (Lausanne). 2024 Sep 16;15:1415424. doi: 10.3389/fendo.2024.1415424. eCollection 2024.
Remnant cholesterol (RC) predicts cardiovascular risk and is associated with a range of diseases, including asthma, hypertension, depression, periodontitis, and alcoholic fatty liver disease. However, its correlation with abdominal aortic calcification (AAC) has not been reported.
Using a cross-sectional approach, this study examined data from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) cycle. Multiple logistic regression, generalized summation models, and subgroup analyses were used in examining the correlation between RC and the prevalence of severe AAC.
The mean age of participants in this study was 57.70 ± 11.73 years, with 142 individuals (9.67%) suffering from severe AAC. The median RC was 0.52 mmol/L (Q1-Q3, 0.36-0.75 mmol/L). Among female participants, a significant positive correlation was observed between RC and severe AAC (per natural log [RC] increment: 2.14; 95% CI, 1.07-4.27). Smooth curve fitting and threshold effect analysis revealed a saturation effect at an RC level of 0.57 mmol/L. Conversely, in male participants, no significant correlation was found between RC and the prevalence of severe AAC (per natural log [RC] increment: 0.88; 95% CI, 0.43-1.78). Our findings suggest a significant interaction between gender and RC in relation to severe AAC ( for interaction = 0.0042).
Higher RC levels were significantly associated with an increased prevalence of severe AAC in women.
残余胆固醇（RC）可预测心血管风险，与多种疾病相关，包括哮喘、高血压、抑郁症、牙周炎和酒精性脂肪肝疾病。然而，其与腹主动脉钙化（AAC）的相关性尚未有报道。
本研究采用横断面研究方法，分析了 2013-2014 年国家健康和营养调查（NHANES）周期的数据。使用多因素逻辑回归、广义求和模型和亚组分析，研究 RC 与重度 AAC 患病率之间的相关性。
本研究参与者的平均年龄为 57.70±11.73 岁，142 人（9.67%）患有重度 AAC。RC 的中位数为 0.52mmol/L（Q1-Q3：0.36-0.75mmol/L）。在女性参与者中，RC 与重度 AAC 呈显著正相关（每自然对数 [RC] 增量：2.14；95%置信区间：1.07-4.27）。平滑曲线拟合和阈值效应分析显示，RC 水平在 0.57mmol/L 时出现饱和效应。相反，在男性参与者中，RC 与重度 AAC 患病率之间无显著相关性（每自然对数 [RC] 增量：0.88；95%置信区间：0.43-1.78）。我们的研究结果表明，RC 与重度 AAC 之间存在显著的性别交互作用（ for interaction=0.0042）。
较高的 RC 水平与女性重度 AAC 的患病率增加显著相关。
