Bhatia Gurjot Kaur, Levy Steven M, Warren John J, Rysavy Oscar A, Saha Punam K, Zhang Xiaoliu, Zeng Erliang
Department of Preventive and Community Dentistry, College of Dentistry, The University of Iowa, Iowa City, Iowa, USA.
Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa, USA.
J Public Health Dent. 2024 Dec;84(4):428-438. doi: 10.1111/jphd.12643. Epub 2024 Sep 7.
To assess the relationships between longitudinal fluoride intakes and bone densitometry outcomes in young adults.
Data were analyzed from the Iowa Fluoride Study and Iowa Bone Development Study, which followed 1,882 infants from birth in 1992. Daily fluoride intakes were assessed using detailed questionnaires sent every 1.5-6 months, and multi-row detector computed tomography (MDCT) scans of distal tibia were obtained from 330 participants aged 23 years. Sex-specific bivariate and multivariable associations with MDCT outcomes were examined using linear regression. Because of the multiple statistical analyses being conducted, p-values < 0.01 were considered statistically significant.
In fully adjusted analyses, no statistically significant (p < 0.01) or suggestive (0.01 < p < 0.05) associations were found between period-specific or cumulative fluoride intake and bone measures for either sex, although there were suggestive positive relationships in unadjusted analyses.
Longitudinal fluoride intakes had little association with bone measures at age 23. As there were no adverse effects from fluoride intake on bone health in young adults, results support the continued use of fluorides, particularly community water fluoridation is the most cost-effective method of dental caries prevention.
评估年轻成年人纵向氟摄入量与骨密度测量结果之间的关系。
对爱荷华氟研究和爱荷华骨骼发育研究的数据进行分析，该研究追踪了1992年出生的1882名婴儿。使用每1.5 - 6个月发送一次的详细问卷评估每日氟摄入量，并从330名23岁参与者中获取胫骨远端的多排探测器计算机断层扫描（MDCT）图像。使用线性回归检验与MDCT结果的性别特异性双变量和多变量关联。由于进行了多项统计分析，p值<0.01被认为具有统计学意义。
在完全调整分析中，未发现特定时期或累积氟摄入量与任何性别的骨测量指标之间存在统计学显著（p < 0.01）或提示性（0.01 < p < 0.05）的关联，尽管在未调整分析中存在提示性的正相关关系。
纵向氟摄入量与23岁时的骨测量指标几乎没有关联。由于氟摄入对年轻成年人的骨骼健康没有不良影响，结果支持继续使用氟化物，特别是社区水氟化是预防龋齿最具成本效益的方法。
