Department of Colorectal Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Biomed Pharmacother. 2024 Oct;179:117402. doi: 10.1016/j.biopha.2024.117402. Epub 2024 Sep 8.
In recent years, the integration of radiotherapy and nanocatalytic medicine has gained widespread attention in the treatment of breast cancer. Herein, the glucose oxidase (GOx) and MnO nanoparticles co-modified multifunctional liposome of GOx-MnO@Lip was constructed for enhanced radiotherapy. Introduction of GOx would not only elevate the glucose consumption to starve the cancer cells, but also increased the endogenous HO level. Meanwhile, high intracellular GSH concentration facilitated the release of Mn to amplify the cytotoxic ·OH through cascade catalytic reactions within the tumor microenvironment, resulting in a favorable tumor suppression rate of 74.45 %. Furthermore, the blood biochemical and blood routine demonstrated that GOx-MnO@Lip had no obvious toxic side effects. Therefore, this work provided a potential vehicle for synergistic cancer starving therapy, chemodynamic therapy and radiotherapy for improving therapeutic efficacy of breast cancer.
近年来，放疗与纳米催化医学的结合在乳腺癌的治疗中受到了广泛关注。在此，构建了葡萄糖氧化酶（GOx）和 MnO 纳米粒子共修饰的多功能脂质体 GOx-MnO@Lip，以增强放疗效果。GOx 的引入不仅可以提高葡萄糖的消耗，从而饿死癌细胞，还可以增加内源性 HO 水平。同时，高浓度的细胞内 GSH 有利于 Mn 的释放，通过级联催化反应在肿瘤微环境中放大细胞毒性·OH，从而使肿瘤抑制率达到 74.45%。此外，血液生化和血常规检测表明，GOx-MnO@Lip 没有明显的毒副作用。因此，这项工作为协同癌症饥饿疗法、化学动力学疗法和放疗提供了一种潜在的载体，以提高乳腺癌的治疗效果。
