Keppler D, Pagano M, Dalet-Fumeron V, Engler R
C R Acad Sci III. 1985;300(13):471-4.
The Cathepsin B-like proteinase, a secretory form of lysosomal cathepsin B, is present in some cancerous exudates (i.e. pleural and ascitic fluids). It has been suggested that this enzyme may be involved in the invasive process, one of the most important aspects of cancer pathology. In the same fluids, two kinds of cysteine-proteinase inhibitors (C.P.I.'s) are found- HMr-CPI (90,000 daltons) and LMr-CPI's (11,000-13,000 daltons). The Cathepsin B-like enzyme is more strongly inhibited by the LMr-CPI's than by the HMr-CPI, the Ki values are 4.0 X 10(-9) M and 1.2 X 10(-7) M respectively. Theses results underline the similarity between this enzyme and the lysosomal Cathepsin B. On the other hand, the inhibitors could play a protective role against tumor invasion.
组织蛋白酶B样蛋白酶是溶酶体组织蛋白酶B的一种分泌形式，存在于一些癌性渗出液中（即胸水和腹水）。有人提出，这种酶可能参与侵袭过程，这是癌症病理学最重要的方面之一。在相同的液体中，发现了两种半胱氨酸蛋白酶抑制剂（C.P.I.）——HMr-CPI（90,000道尔顿）和LMr-CPI（11,000 - 13,000道尔顿）。组织蛋白酶B样酶受LMr-CPI的抑制作用比受HMr-CPI的抑制作用更强，其Ki值分别为4.0×10⁻⁹ M和1.2×10⁻⁷ M。这些结果强调了这种酶与溶酶体组织蛋白酶B之间的相似性。另一方面，这些抑制剂可能对肿瘤侵袭起到保护作用。
