Affiliated Hospital of Southwest Medical University, Department of Otolaryngology Head and Neck Surgery, Sichuan, China.
School of Basic Medicine, Department of Pathogen Biology, Southwest Medical University, Public Center of Experimental Technology of Pathogen Biology Technology Platform, Sichuan, China.
Braz J Otorhinolaryngol. 2024 Nov-Dec;90(6):101491. doi: 10.1016/j.bjorl.2024.101491. Epub 2024 Aug 12.
Continuous research on the structure and function of intestinal microecology has confirmed the association between gut microbiota and the occurrence, development, and outcome of allergic diseases. Here, we explored the genetic causality between gut microbiota and rhinitis.
We conducted a two-sample Mendelian Randomization (MR) study to investigate the genetic causal relationship between gut microbiota and allergic rhinitis and vasomotor rhinitis. Genetic variations in the human gut microbiota were obtained from the summary statistics of the MiBioGen study. Genome-wide summary statistics of rhinitis were obtained from the FinnGen consortium. The causal effect between gut microbiota and rhinitis was assessed using the inverse variance weighted, MR-Egger regression, and weighted median methods. In addition, sensitivity analyses were conducted using different methods, including maximum likelihood, simple mode, and weighted model methods.
The IVW approach revealed a causal association of the genus Ruminococcus gauvreauii group with an increased risk of allergic rhinitis (IVW Odds Ratio [OR = 1.26] [1.04, 1.53], p-value = 0.01645). In addition, the genus Fusicatenibacter (IVW OR = 1.20 [1.02, 1.41], p-value = 0.02868) was causally associated with an increased risk of vasomotor rhinitis.
Gut microbiota belonging to different genera exert different effects on allergic rhinitis and vasomotor rhinitis, including reducing the risk of rhinitis, and increasing the risk of rhinitis. New insights into the mechanisms of underlying gut microbiota-associated rhinitis are provided.
Level 5.
对肠道微生态结构和功能的持续研究证实了肠道微生物群与过敏疾病的发生、发展和结局之间的关联。本研究旨在探讨肠道微生物群与鼻炎之间的遗传因果关系。
我们进行了两样本 Mendelian Randomization（MR）研究，以调查肠道微生物群与变应性鼻炎和血管舒缩性鼻炎之间的遗传因果关系。从 MiBioGen 研究的汇总统计数据中获得了人类肠道微生物群的遗传变异。从 FinnGen 联盟获得了鼻炎的全基因组汇总统计数据。使用逆方差加权、MR-Egger 回归和加权中位数方法评估肠道微生物群与鼻炎之间的因果关系。此外，还使用不同的方法（包括最大似然、简单模式和加权模型方法）进行敏感性分析。
IVW 方法表明，Ruminococcus gauvreauii 属与变应性鼻炎风险增加之间存在因果关系（IVW 比值比 [OR] = 1.26 [1.04, 1.53]，p 值 = 0.01645）。此外，Fusicatenibacter 属（IVW OR = 1.20 [1.02, 1.41]，p 值 = 0.02868）与血管舒缩性鼻炎风险增加之间存在因果关系。
属于不同属的肠道微生物群对变应性鼻炎和血管舒缩性鼻炎有不同的影响，包括降低鼻炎的风险和增加鼻炎的风险。为肠道微生物群相关鼻炎的潜在机制提供了新的见解。
5 级。
