Ríos-Deidán Carlos, Reyes Maria-Soledad, Acosta-Castillo Tamara, Escalante-Fiallos Edgar, Villacrés-Silva Diana
Otorhinolaryngology Department of Medical Sciences Faculty, Central University of Ecuador, 170527 Quito, Ecuador.
Pathology Unit, Ecuadorian Institute of Social Security Sangolquí, Sangolquí, Ecuador.
Indian J Otolaryngol Head Neck Surg. 2023 Dec;75(4):3364-3372. doi: 10.1007/s12070-023-03922-y. Epub 2023 Jun 22.
Demonstrate the histological remodeling changes in the turbinates, identify the frequency of the two forms of rhinitis in the samples studied and determine the remodeling differences found in the two variants. Patients attended an otolaryngology service at the Social Security Hospital of city Sangolqui-Ecuador from February 2016 to June 2017. The allergic variant was determined when eosinophils were found by higher magnification field and non-allergic when they were not found in the submucosal segment. Epithelial, inflammatory, and stromal markers were analyzed. One hundred twenty histopathological samples were analyzed, 75% presented allergic rhinitis, the age averaged 36.2 years. When we compared between the allergic and non-allergic variants: epithelial and stromal markers we had significant differences, as well as between each of its components; except fibrosis. In relation to the inflammatory pattern, there were significant differences between the number of mast cells and stromal markers with eosinophils > 10 by field. The allergic type corresponded to 75% of patients with persistent severe rhinitis who underwent turbinectomy. Regarding remodeling, there was a statistically significant difference in favor of the allergic variant. Eosinophilia greater than 10 was directly related to mastocytosis and subepithelial edema.
展示鼻甲的组织学重塑变化，确定所研究样本中两种鼻炎形式的发生率，并确定两种变体中发现的重塑差异。2016年2月至2017年6月期间，患者在厄瓜多尔桑戈尔基市社会保障医院的耳鼻喉科就诊。当在高倍视野下发现嗜酸性粒细胞时确定为变应性变体，当在黏膜下节段未发现嗜酸性粒细胞时确定为非变应性变体。分析上皮、炎症和基质标志物。分析了120份组织病理学样本，75%呈现变应性鼻炎，平均年龄为36.2岁。当我们比较变应性和非变应性变体时：上皮和基质标志物存在显著差异，其各个成分之间也存在显著差异；除纤维化外。关于炎症模式，肥大细胞数量与每视野嗜酸性粒细胞>10的基质标志物之间存在显著差异。变应性类型对应于75%接受鼻甲切除术的持续性重度鼻炎患者。关于重塑，变应性变体具有统计学上的显著差异。嗜酸性粒细胞增多大于10与肥大细胞增多症和上皮下水肿直接相关。
