Bonuccelli U, Murialdo G, Martino E, Lecchini S, Bonura M L, Bambini G, Murri L
Clin Neuropharmacol. 1985;8(2):165-74. doi: 10.1097/00002826-198506000-00006.
The effects of carbamazepine (CBZ) on spontaneous secretion of prolactin (PRL) and after stimulation with thyrotropin releasing hormone (TRH) were evaluated. Volunteer subjects after acute CBZ administration, and epileptic subjects with complex partial seizures chronically treated with CBZ, were examined. In an epileptic group, CBZ did not change TRH stimulatory effect on PRL secretion. No appreciable changes of PRL spontaneous secretion were observed, and only a small increase of sleep-entrained values with preservation of the normal secretory circadian rhythm was noted, both in normal subjects and in epileptic subjects. This result could be explained by a serotoninergic activity of PRL changes produced by CBZ in these various conditions agrees with the absence of published reports of CBZ side effects associated with hyperprolactinemia.
评估了卡马西平（CBZ）对催乳素（PRL）自发分泌以及促甲状腺激素释放激素（TRH）刺激后分泌的影响。对急性给予CBZ后的志愿者受试者以及长期接受CBZ治疗的复杂部分性发作癫痫患者进行了检查。在癫痫组中，CBZ并未改变TRH对PRL分泌的刺激作用。未观察到PRL自发分泌有明显变化，并且在正常受试者和癫痫患者中均仅注意到睡眠诱导值有小幅增加，同时正常分泌昼夜节律得以保留。这一结果可以用CBZ在这些不同情况下产生的PRL变化的5-羟色胺能活性来解释，这与未发表的关于CBZ与高催乳素血症相关副作用的报告缺乏一致。
