Galli R, Michelini S, Bartalena L, Massetani R, Pani L, Grasso L, Cassano G B, Martino E, Purdy R H, Murri L
Istituto di Clinica Neurologica, Università di Pisa.
Ital J Neurol Sci. 1996 Aug;17(4):277-81. doi: 10.1007/BF01997786.
The 3alpha-hydroxy metabolites of progesterone (P), 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone, A-PREG) and 3alpha-hydroxy-5beta-pregnan-20-one (pregnanolone, PREG), have been found to be among the most potent ligands of gamma-aminobutyric (GABA)-A receptors; in experimental animals, they have been found to have anxiolytic, hypnotic and anticonvulsant effects. Similar to those of the benzodiazepines and barbiturates that interact with GABA-A receptors. The present study was undertaken to determine plasma A-PREG and PREG concentrations in the luteal phase in women with partial epilepsy, in order to determine if an impaired metabolism of P occurs in this convulsive disorder. We measured plasma P, A-PREG and PREG levels in 15 women with partial epilepsy in the intercritical phase, and in 15 age-matched healthy women, during the luteal phase of the ovarian cycle (22nd-24th day). The mean plasma +/- S.E. A-PREG levels (three blood samples) were 0.7 +/- 0.6 ng/ml in the epileptic women and 0.5 +/- 0.2 ng/ml in controls, with no significant difference between the two groups (p = NS); the PREG levels were also similar (1.4 +/- 1 ng/ml and 1 +/- 1.1 ng/ml, respectively: p = NS). A significant correlation was found between P levels and both A-PREG and PREG levels (r = 0.72, p < 0.001 and r = 0.79, p < 0.001, respectively). There were no significant differences between the two groups in terms of serum adrenocorticotropic hormone, cortisol, dihydroepiandrosterone-sulfate, follicle stimulating hormone, prolactin, luteinizing hormone or estradiol levels.
孕酮（P）的3α-羟基代谢产物，3α-羟基-5α-孕烷-20-酮（别孕烯醇酮，A-PREG）和3α-羟基-5β-孕烷-20-酮（孕烯醇酮，PREG），已被发现是γ-氨基丁酸（GABA）-A受体最有效的配体之一；在实验动物中，它们已被发现具有抗焦虑、催眠和抗惊厥作用。与与GABA-A受体相互作用的苯二氮䓬类和巴比妥类药物类似。本研究旨在测定部分癫痫女性黄体期血浆中A-PREG和PREG的浓度，以确定在这种惊厥性疾病中是否存在P代谢受损的情况。我们在15名部分癫痫女性的发作间期以及15名年龄匹配的健康女性的卵巢周期黄体期（第22 - 24天）测量了血浆P、A-PREG和PREG水平。癫痫女性血浆A-PREG平均水平（三个血样）为0.7±0.6 ng/ml，对照组为0.5±0.2 ng/ml，两组之间无显著差异（p =无显著性差异）；PREG水平也相似（分别为1.4±1 ng/ml和1±1.1 ng/ml：p =无显著性差异）。发现P水平与A-PREG和PREG水平均存在显著相关性（分别为r = 0.72，p < 0.001和r = 0.79，p < 0.001）。两组在血清促肾上腺皮质激素、皮质醇、硫酸脱氢表雄酮、卵泡刺激素、催乳素、黄体生成素或雌二醇水平方面无显著差异。
