对头颈部肿瘤放疗患者放射性口腔黏膜炎相关因素的分析。
Analysis of factors related to radiation-induced oral mucositis in patients with head and neck tumors undergoing radiotherapy.
作者信息
Tan Xiao-Juan, Liu Jing-Jing, Deng Yi-Kun, Li Xue-Dong, Yang Wei-Xia, Hu Xin, Xu Li-Ming
机构信息
Department of Nursing, Hospital of Stomatology Tianjin Medical University, Tianjin, 300070, China.
Department of Emergency Comprehensive, Hospital of Stomatology Tianjin Medical University, Tianjin, 300070, China.
出版信息
J Stomatol Oral Maxillofac Surg. 2025 Mar;126(2):102042. doi: 10.1016/j.jormas.2024.102042. Epub 2024 Sep 5.
OBJECTIVE
To explore the risk factors of radiation-induced oral mucositis (RIOM) in patients with head and neck tumors undergoing radiotherapy.
METHODS
A retrospective collection was conducted on patients with head and neck tumors who underwent radiotherapy and chemotherapy in our hospital from April 1, 2015 to April 1, 2019. They were divided into an incidence group (n = 48) and a non-incidence group (n = 76) based on whether RIOM occurred, and relevant data was collected for comparison.
RESULTS
There were statistically significant differences between the two groups of patients in terms of tumor type, smoking percentage, education level percentage, tumor stage, oral mucosal inflammation stage, radiotherapy dose, mucosal protectants, and oral hygiene condition(P < 0.05); The regression analysis results showed that smoking (OR=1.274, 95 % CI: 1.095-2.007), high-dose radiotherapy (OR=1.223, 95 % CI: 1.098-2.077), and poor oral hygiene (OR=1.367, 95 % CI: 1.024-2.890) were risk factors for RIOM.
CONCLUSION
Smoking, high-dose radiotherapy, and poor oral hygiene were risk factors for RIOM in head and neck patients after radiotherapy and chemotherapy.
目的
探讨头颈部肿瘤放疗患者放射性口腔黏膜炎（RIOM）的危险因素。
方法
回顾性收集2015年4月1日至2019年4月1日在我院接受放疗及化疗的头颈部肿瘤患者。根据是否发生RIOM将其分为发病组（n = 48）和未发病组（n = 76），收集相关数据进行比较。
结果
两组患者在肿瘤类型、吸烟比例、受教育程度比例、肿瘤分期、口腔黏膜炎症分期、放疗剂量、黏膜保护剂及口腔卫生状况方面差异有统计学意义（P < 0.05）；回归分析结果显示，吸烟（OR = 1.274，95%CI：1.095 - 2.007）、高剂量放疗（OR = 1.223，95%CI：1.098 - 2.077）及口腔卫生差（OR = 1.367，95%CI：1.024 - 2.890）是RIOM的危险因素。
结论
吸烟、高剂量放疗及口腔卫生差是头颈部肿瘤患者放化疗后发生RIOM的危险因素。
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