Department of Zoology, University of Delhi, 110007, India.
Ramjas College, University of Delhi, Delhi 110007, India.
Peptides. 2024 Nov;181:171293. doi: 10.1016/j.peptides.2024.171293. Epub 2024 Sep 5.
Asprosin is a recently discovered adipokine reported to be involved in the modulation of mammalian gonadal functions. Preliminary investigations suggest its role in regulation of ovarian functions in rodents as well as bovids. In addition, increased levels of the adipokine during human ovarian pathophysiologies implicate it in disease progression and severity. The present study evidenced high expression of asprosin in ovaries of juvenile, pubertal and adult mice while expression was significantly low in ageing ovaries. Further, asprosin stimulated expression of markers for ovarian folliculogenesis (Scf, c-Kit, Gdf9, Bmp6, Fshr, Lhr) and steroidogenesis (3β-Hsd) in adult mice. In addition to exploring concentration-dependent effect of asprosin, the study implicates asprosin as an age-dependent modulator of ovarian functions as treatment of ovaries with asprosin led to upregulation of Fshr, c-Kit, Bmp6, and Gdf9 in both adult and juvenile ovaries, Lhr only in adults while that of Scf only in juvenile ovaries. The current study is first to report an age-dependent expression and role of asprosin in murine ovaries.
脑啡肽是一种新发现的脂肪因子，据报道它参与了哺乳动物性腺功能的调节。初步研究表明，它在啮齿动物和牛科动物的卵巢功能调节中发挥作用。此外，人类卵巢病理生理学中脂肪因子水平的升高表明其与疾病的进展和严重程度有关。本研究证实脑啡肽在幼年、青春期和成年小鼠的卵巢中表达水平较高，而在衰老卵巢中表达水平显著降低。此外，脑啡肽在成年小鼠中刺激卵巢卵泡发生（Scf、c-Kit、Gdf9、Bmp6、Fshr、Lhr）和类固醇生成（3β-Hsd）标志物的表达。除了探索脑啡肽的浓度依赖性作用外，该研究还表明脑啡肽是卵巢功能的一种年龄依赖性调节剂，因为用脑啡肽处理卵巢会导致 Fshr、c-Kit、Bmp6 和 Gdf9 在成年和幼年卵巢中的上调，Lhr 仅在成年卵巢中，而 Scf 仅在幼年卵巢中。本研究首次报道了脑啡肽在小鼠卵巢中的年龄依赖性表达和作用。
