Evans Jack T, Buscot Marie-Jeanne, Fraser Brooklyn J, Juonala Markus, Guo Yajun, Fernandez Camilo, Kähönen Mika, Sabin Matthew A, Armstrong Matthew K, Viikari Jorma S A, Bazzano Lydia A, Raitakari Olli T, Magnussen Costan G
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia; Department of Health, Tasmanian Government, Hobart, Australia.
Prev Med. 2024 Dec;189:108128. doi: 10.1016/j.ypmed.2024.108128. Epub 2024 Sep 6.
Child and adult body mass index (BMI) associates with adult carotid artery intima-media thickness (cIMT). However, the relative contribution of BMI at different life-periods on adult cIMT has not been quantified. This study aimed to determine the life-course model that best explains the relative contribution of BMI at different life-periods (childhood, adolescence, and young-adulthood) on cIMT in adulthood.
BMI was calculated from direct measurements of height and weight at up to seven time-points from childhood to adulthood (1973-2007) among 2485 participants of the Cardiovascular Risk in Young Finns Study (YFS) and 1271 participants in the Bogalusa Heart Study (BHS). BMI measures at three ages representative of childhood (9-years), adolescence (18 years) and young-adulthood (30 years) life-periods were used. B-mode ultrasound was used to measure common cIMT in adulthood (>30 years). Associations were evaluated using the Bayesian relative life-course exposure model.
In both cohorts, cumulative exposure to higher levels of BMI across the life-course was associated with greater cIMT. Of the examined life-periods, BMI in young-adulthood provided the greatest relative contribution towards the development of adult cIMT for YFS (49.9 %, 95 % CrI = 34-68 %) and white BHS participants (48.6 %, 95 % CrI = 9-86 %), whereas BMI in childhood had the greatest relative contribution for black BHS participants (54.0 %, 95 % CrI = 8-89 %).
Although our data suggest sensitive periods in the life-course where prevention and intervention aimed at reducing BMI might provide most benefit in limiting the effects of BMI on cIMT, maintaining lower BMI across the life-course appears to be optimal.
儿童和成人的体重指数（BMI）与成人颈动脉内膜中层厚度（cIMT）相关。然而，不同生命阶段的BMI对成人cIMT的相对贡献尚未得到量化。本研究旨在确定能最好地解释不同生命阶段（儿童期、青春期和青年期）的BMI对成年期cIMT相对贡献的生命历程模型。
在芬兰青年人心血管风险研究（YFS）的2485名参与者和博加卢萨心脏研究（BHS）的1271名参与者中，从儿童期到成年期（1973 - 2007年）多达七个时间点直接测量身高和体重来计算BMI。使用了代表儿童期（9岁）、青春期（18岁）和青年期（30岁）生命阶段的三个年龄的BMI测量值。使用B型超声测量成年期（>30岁）的颈总动脉内膜中层厚度。使用贝叶斯相对生命历程暴露模型评估相关性。
在两个队列中，整个生命历程中暴露于较高水平的BMI与更大的cIMT相关。在所研究的生命阶段中，青年期的BMI对YFS（49.9%，95% CrI = 34 - 68%）和白人BHS参与者成年期cIMT的发展贡献最大，而儿童期的BMI对黑人BHS参与者的相对贡献最大（54.0%，95% CrI = 8 - 89%）。
虽然我们的数据表明生命历程中存在敏感时期，在这些时期针对降低BMI的预防和干预可能对限制BMI对cIMT的影响最有益，但在整个生命历程中保持较低的BMI似乎是最佳的。
