Department of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, 1215 Medical Center Drive, Nashville, TN 27232, USA.
Department of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, 1215 Medical Center Drive, Nashville, TN 27232, USA.
Surg Oncol Clin N Am. 2024 Oct;33(4):697-709. doi: 10.1016/j.soc.2024.07.001. Epub 2024 Aug 1.
Oropharyngeal squamous cell carcinoma (OPSCC) related to human papillomavirus (HPV) infection has better survival outcomes compared to non-HPV-related OPSCC, leading to efforts to de-escalate the intensity of treatment to reduce associated morbidity. This article reviews recent clinical efforts to explore different de-escalation frameworks with a particular emphasis on the emergence of transoral robotic surgery and surgically driven de-escalation approaches. It discusses the current evidence for incorporating surgery into an evolving treatment paradigm for HPV-related OPSCC.
人乳头瘤病毒（HPV）相关口咽鳞状细胞癌（OPSCC）的生存结局优于非 HPV 相关 OPSCC，这促使人们努力降低治疗强度以减少相关发病率。本文综述了近期在探索不同降级框架方面的临床努力，特别强调了经口机器人手术的出现和手术驱动的降级方法。本文讨论了将手术纳入 HPV 相关 OPSCC 不断发展的治疗模式中的现有证据。
