患有获得性免疫缺陷综合征（艾滋病）和艾滋病相关综合征（ARC）的同性恋者对外源性白细胞介素-2的淋巴细胞反应异常。
Abnormal lymphocyte response to exogenous interleukin-2 in homosexuals with acquired immune deficiency syndrome (AIDS) and AIDS related complex (ARC).
作者信息
Murray J L, Hersh E M, Reuben J M, Munn C G, Mansell P W
出版信息
Clin Exp Immunol. 1985 Apr;60(1):25-30.
Abstract
Interleukin-2 (IL-2) production as well as the response of lymphocytes to exogenous IL-2 was measured in asymptomatic homosexuals, patients with acquired immune deficiency syndrome (AIDS), and homosexuals with prodromal symptoms. IL-2 production following lectin stimulation was not significantly different in homosexuals compared to age matched heterosexual controls. In contrast, the response of lymphocytes to exogenous IL-2 was significantly decreased in AIDS and homosexuals with prodromal symptoms compared to asymptomatic homosexuals and heterosexual controls. These data, combined with the data of others, suggest that an underlying immune defect in AIDS is abnormal IL-2 receptor expression and resultant poor IL-2 response.
摘要
在无症状同性恋者、获得性免疫缺陷综合征（艾滋病）患者以及有前驱症状的同性恋者中，检测了白细胞介素-2（IL-2）的产生以及淋巴细胞对外源性IL-2的反应。与年龄匹配的异性恋对照相比，同性恋者在凝集素刺激后IL-2的产生没有显著差异。相比之下，与无症状同性恋者和异性恋对照相比，艾滋病患者和有前驱症状的同性恋者中淋巴细胞对外源性IL-2的反应显著降低。这些数据，与其他研究数据相结合，表明艾滋病潜在的免疫缺陷是IL-2受体表达异常以及由此导致的IL-2反应不佳。
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