一名获得性免疫缺陷综合征（艾滋病）患者体内白细胞介素-2的产生及对外源性白细胞介素-2的反应
Interleukin-2 production and response to exogenous interleukin-2 in a patient with the acquired immune deficiency syndrome (AIDS).
作者信息
Hauser G J, Bino T, Rosenberg H, Zakuth V, Geller E, Spirer Z
出版信息
Clin Exp Immunol. 1984 Apr;56(1):14-7.
Abstract
The ability of lymphocytes from a patient suffering from the acquired immune deficiency syndrome (AIDS) to produce interleukin-2 (IL-2) was found to be comparable to that of his healthy sex partner and to that of a normal control. Addition of exogenous IL-2 to lymphocyte cultures did not improve the poor mitogen response to phytohaemagglutinin in this patient. Our data suggest that the underlying defect in this AIDS patient is due to an IL-2 receptor defect.
摘要
研究发现，一名获得性免疫缺陷综合征（艾滋病）患者的淋巴细胞产生白细胞介素-2（IL-2）的能力与他健康的性伴侣以及正常对照者相当。向该患者的淋巴细胞培养物中添加外源性IL-2并不能改善其对植物血凝素的不良有丝分裂原反应。我们的数据表明，这名艾滋病患者的潜在缺陷是由于IL-2受体缺陷所致。
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