Department of Physics and Astronomy, University of California, Los Angeles, Los Angeles, California.
Department of Physics and Astronomy, University of California, Los Angeles, Los Angeles, California.
Biophys J. 2024 Oct 15;123(20):3550-3557. doi: 10.1016/j.bpj.2024.09.006. Epub 2024 Sep 6.
We propose a model for the feedback control processes that underlie the robustness and high sensitivity of mechanosensory hair cells. Our model encompasses self-tuning active processes intrinsic to these cells, which drive the amplification of mechanical stimuli by consuming metabolic energy, and a neural input process that protects these cells from damage caused by powerful stimuli. We explore the effects of these two feedback mechanisms on mechanical self-oscillations of the sense cells and their response to external forcing.
我们提出了一个模型，用于解释机械敏感毛细胞的鲁棒性和高灵敏度背后的反馈控制过程。我们的模型包含了这些细胞固有的自调节主动过程，这些过程通过消耗代谢能量来放大机械刺激，以及一个神经输入过程，该过程可以保护这些细胞免受强刺激造成的损伤。我们探讨了这两个反馈机制对感觉细胞的机械自激振荡及其对外力响应的影响。
