Martins-Duarte Paula Maria, Hessel Gabriel, Ribeiro Antônio Fernando, Lima Marson Fernando Augusto, Colella-Santos Maria Francisca
Centro de Investigação em Pediatria da Faculdade de Ciências Médicas da Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
Centro de Investigação em Pediatria da Faculdade de Ciências Médicas da Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
J Pediatr (Rio J). 2025 Jan-Feb;101(1):96-102. doi: 10.1016/j.jped.2024.06.013. Epub 2024 Sep 5.
This study aims to evaluate the central auditory system of children and adolescents with cystic fibrosis through behavioral assessment of central auditory processing and electrophysiological tests to investigate short and long-latency auditory potentials, comparing them with the results obtained in the control group.
117 from 7 to 21 years old patients were evaluated, 57 of them with cystic fibrosis and 60 of the control group, using behavioral evaluation of central auditory processing, auditory brainstem response and long latency auditory evoked potential. The comparison of the research groups was performed using ANOVA for Auditory Brain Response and P300 responses and Wilcoxon and Mann-Whitney tests for Central Auditory Processing responses.
A statistically significant difference was found in the results of the GIN test between the groups and in the auditory brainstem response latency responses in waves I and V in the comparison between the groups with higher latencies in the study group. A difference was also found between latencies in the interpeak intervals I-III and III-V. The long latency auditory evoked potential analysis shows a statistically significant difference in the latency of the P300 potential, with higher latencies in the study group.
Cystic fibrosis participants presented worse performance in the gaps-in-noise test compared to the control group in the evaluation of central auditory processing, which indicates impairment of temporal resolution auditory ability. They also showed increased latency in I and V waves of auditory brainstem response, as well as an increase P300 latency in long latency auditory evoked potential.
本研究旨在通过对中枢听觉处理进行行为评估以及电生理测试，以评估患有囊性纤维化的儿童和青少年的中枢听觉系统，研究短潜伏期和长潜伏期听觉电位，并将其与对照组的结果进行比较。
对117名7至21岁的患者进行了评估，其中57名患有囊性纤维化，60名作为对照组，采用中枢听觉处理行为评估、听觉脑干反应和长潜伏期听觉诱发电位进行评估。研究组之间的比较采用方差分析评估听觉脑反应和P300反应，采用Wilcoxon和Mann-Whitney检验评估中枢听觉处理反应。
两组之间在GIN测试结果以及研究组中潜伏期较长的组间比较中，I波和V波的听觉脑干反应潜伏期存在统计学显著差异。在峰间期I-III和III-V的潜伏期之间也发现了差异。长潜伏期听觉诱发电位分析显示P300电位潜伏期存在统计学显著差异，研究组的潜伏期更长。
在中枢听觉处理评估中，与对照组相比，患有囊性纤维化的参与者在噪声间隙测试中的表现更差，这表明其听觉时间分辨率能力受损。他们还表现出听觉脑干反应I波和V波潜伏期增加，以及长潜伏期听觉诱发电位中P300潜伏期增加。
