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评估体重指数对食管裂孔疝修补术后围手术期结局和短期复发的影响。

Assessing the effect of body mass index on perioperative outcomes and short-term recurrence after paraesophageal hernia repair.

机构信息

Department of General and Thoracic Surgery, Virginia Mason Franciscan Health, Seattle, WA, USA.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

出版信息

Dis Esophagus. 2024 Oct 28;37(11). doi: 10.1093/dote/doae072.

DOI:10.1093/dote/doae072
PMID:39245810
Abstract

Previous assessments suggest that surgical results of paraesophageal hernia (PEH) repair were negatively impacted by increasing levels of obesity. A better understanding of the association of obesity on outcomes of PEH repair will support surgeons making evidence-based decisions on the surgical candidacy of individual patients. This single institution retrospective cohort study included 884 consecutive patients with giant PEH undergoing surgical repair between 1 January 2000 and 30 June 2020. Preoperative body mass index (BMI) was documented at the time of surgery. Main outcomes included perioperative blood loss, length of hospital stay, major complications, early hernia recurrence, and mortality. The mean (standard deviation [SD]) age at surgery was 68.4 (11.1), and 645 (73.0%) were women. Among the 884 patients, 875 had a documented immediate preoperative BMI and were included in the analysis. Mean (SD) BMI was 29.24 (4.91) kg/m2. Increasing BMI was not associated with increased perioperative blood loss (coefficient, 0.01; 95% confidence interval [CI], -0.01 to 0.02), prolonged length of stay (coefficient, -0.01; 95% CI, -0.02 to 0.01), increased incidence of recurrent hernia (odds ratio [OR], 1.03; 95% CI, 0.95-1.10), or increased major complications (OR, 0.93; 95% CI, 0.82-1.05). The 90-day mortality rate was 0.3%. Furthermore, when compared with the normal weight group, overweight and all levels of obesity were not related to unfavorable outcomes. No association was found between BMI and perioperative outcomes or short-term recurrence in patients undergoing PEH repair. Although preoperative weight loss is advisable, a higher BMI should not preclude or delay surgical management of giant PEH.

摘要

先前的评估表明,食管裂孔疝(PEH)修复的手术结果受到肥胖程度增加的负面影响。更好地了解肥胖对 PEH 修复结果的影响,将有助于外科医生根据个体患者的情况做出基于证据的手术决策。这项单机构回顾性队列研究纳入了 884 例接受手术修复的巨大食管裂孔疝连续患者,手术时间为 2000 年 1 月 1 日至 2020 年 6 月 30 日。术前体重指数(BMI)在手术时记录。主要结局包括围手术期失血量、住院时间、主要并发症、早期疝复发和死亡率。手术时的平均(标准差[SD])年龄为 68.4(11.1)岁,其中 645 例(73.0%)为女性。在 884 例患者中,875 例有记录的术前即刻 BMI,并纳入分析。平均(SD)BMI 为 29.24(4.91)kg/m2。BMI 增加与围手术期失血量增加无关(系数,0.01;95%置信区间[CI],-0.01 至 0.02)、住院时间延长(系数,-0.01;95%CI,-0.02 至 0.01)、疝复发发生率增加(比值比[OR],1.03;95%CI,0.95-1.10)或主要并发症增加(OR,0.93;95%CI,0.82-1.05)无关。90 天死亡率为 0.3%。此外,与正常体重组相比,超重和所有肥胖水平与不良结局无关。PEH 修复患者的 BMI 与围手术期结局或短期复发之间无关联。虽然术前减肥是可取的,但较高的 BMI 不应排除或延迟对巨大食管裂孔疝的手术治疗。

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