Breast Center, West China Hospital of Sichuan University, Guoxuexiang Street, Chengdu, China.
Department of General Surgery, West China Hospital of Sichuan University, Guoxuexiang Street, Chengdu, China.
J Int Med Res. 2024 Sep;52(9):3000605241272609. doi: 10.1177/03000605241272609.
The glomus tumor is a rare neoplasm that is typically found subungually in the extremities and functions as a specialized neurovascular organ. An extremely rare site for glomus tumors is the breast, with only a few reported cases. Breast glomus tumors present with three typical clinical signs: dull pain, focal tenderness, and cold sensitivity. Less than 10% of all glomus tumors are malignant. We herein present a case of a malignant glomus tumor originating in the breast. Distant metastasis was ruled out, and the tumor was completely resected. However, the patient unexpectedly developed rapid systemic metastasis, detected 5 weeks after tumor removal. Despite the administration of analgesics and targeted therapy, the patient died 1 month later. When treating patients with undiagnosed breast tumors, clinicians should pay attention to unexplained and repeatedly reported symptoms and consider the possibility of a rare disease. Our literature search revealed no cases of malignant glomus tumors originating in the breast, making this case the first of its kind.
血管球瘤是一种罕见的肿瘤，通常在四肢的指甲下发现，是一种特殊的神经血管器官。血管球瘤极为罕见的部位是乳房，仅有少数几例报道。乳房血管球瘤表现出三个典型的临床特征：钝痛、局部压痛和对冷敏感。不到 10%的血管球瘤是恶性的。本文报告了一例起源于乳房的恶性血管球瘤。排除了远处转移，并完全切除了肿瘤。然而，患者在肿瘤切除后 5 周意外发生快速全身转移。尽管给予了镇痛和靶向治疗，患者仍在 1 个月后死亡。当治疗原因不明的乳腺肿瘤的患者时，临床医生应注意不明原因和反复报告的症状，并考虑罕见疾病的可能性。我们的文献检索未发现起源于乳房的恶性血管球瘤病例，使本病例成为首例。
