Thai Michelle, Başgöze Zeynep, Westlund Schreiner Melinda, Roediger Donovan J, Falke Chloe A, Mueller Bryon A, Fiecas Mark B, Quevedo Karina, Pfeifer Jennifer H, Klimes-Dougan Bonnie, Cullen Kathryn R
Department of Psychology, University of Minnesota, Twin Cities, MN, USA.
Center for Depression, Anxiety, and Stress Research, McLean Hospital, Belmont, MA, USA.
Psychol Med. 2024 Sep 9:1-12. doi: 10.1017/S0033291724001399.
Adolescence is a critical period for brain development, consolidation of self-understanding, and onset of non-suicidal self-injury (NSSI). This study evaluated the RDoC (Research Domain Criteria) sub-construct of Self-Knowledge in relation to adolescent NSSI using multiple units of analysis.
One hundred and sixty-four adolescents assigned female at birth (AFAB), ages 12-16 years with and without a history of NSSI entered a study involving clinical assessment and magnetic resonance imaging (MRI), including structural, resting-state functional MRI (fMRI), and fMRI during a self-evaluation task. For imaging analyses, we used an defined Self Network (anterior cingulate, orbitofrontal, and posterior cingulate cortices; precuneus). We first examined interrelationships among multi-level Self variables. We then evaluated the individual relationships between NSSI severity and multi-level Self variables (self-report, behavior, multi-modal brain Self Network measures), then conducted model testing and multiple regression to test how Self variables (together) predicted NSSI severity.
Cross-correlations revealed key links between self-reported global self-worth and self-evaluation task behavior. Individually, greater NSSI severity correlated with lower global self-worth, more frequent and faster negative self-evaluations, lower anterior Self Network activation during self-evaluation, and lower anterior and posterior Self Network resting-state connectivity. Multiple regression analysis revealed the model including multi-level Self variables explained NSSI better than a covariate-only model; the strongest predictive variables included self-worth, self-evaluation task behavior, and resting-state connectivity.
Disruptions in Self-Knowledge across multiple levels of analysis relate to NSSI in adolescents. Findings suggest potential neurobiological treatment targets, potentially enhancing neuroplasticity in Self systems to facilitate greater flexibility (more frequently positive) of self-views in AFAB adolescents.
青春期是大脑发育、自我认知巩固以及非自杀性自伤（NSSI）开始的关键时期。本研究使用多种分析单元评估了与青少年NSSI相关的自我认知的研究领域标准（RDoC）子结构。
164名出生时被指定为女性（AFAB）、年龄在12至16岁之间且有或无NSSI病史的青少年参与了一项涉及临床评估和磁共振成像（MRI）的研究，包括结构成像、静息态功能MRI（fMRI）以及自我评估任务期间的fMRI。对于成像分析，我们使用了一个定义的自我网络（前扣带回、眶额皮质和后扣带回皮质；楔前叶）。我们首先检查了多层次自我变量之间的相互关系。然后我们评估了NSSI严重程度与多层次自我变量（自我报告、行为、多模态大脑自我网络测量）之间的个体关系，接着进行模型测试和多元回归，以测试自我变量（共同）如何预测NSSI严重程度。
交叉相关性揭示了自我报告的总体自我价值与自我评估任务行为之间的关键联系。单独来看，更高的NSSI严重程度与更低的总体自我价值、更频繁和更快的负面自我评估、自我评估期间前自我网络激活降低以及前、后自我网络静息态连通性降低相关。多元回归分析显示，包含多层次自我变量的模型比仅包含协变量的模型能更好地解释NSSI；最强的预测变量包括自我价值、自我评估任务行为和静息态连通性。
多层次分析中自我认知的破坏与青少年的NSSI有关。研究结果表明了潜在的神经生物学治疗靶点，可能增强自我系统中的神经可塑性，以促进AFAB青少年自我观点更具灵活性（更频繁地为积极）。
