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基于基因组的早期检测筛查:胃肠道癌症前瞻性试验及新兴策略的文献综述

Genomic-Based Early Detection Screening: A Literature Review of Prospective Trials and Emerging Strategies for Gastrointestinal Cancers.

作者信息

Tizpa Eemon, Sharzehi Kaveh, Nabavizadeh Nima

机构信息

Radiation Oncology, Washington State University Elson S. Floyd College of Medicine, Spokane, USA.

Gastroenterology and Hepatology, Oregon Health and Science University School of Medicine, Portland, USA.

出版信息

Cureus. 2024 Sep 7;16(9):e68881. doi: 10.7759/cureus.68881. eCollection 2024 Sep.

DOI:10.7759/cureus.68881
PMID:39246640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11380558/
Abstract

Numerous genomic-based early detection screening tests are being developed. These tests have the potential to revolutionize current single-organ screening paradigms, especially in gastrointestinal cancers. In this review, we underscore the performance of these genomic-based early detection tests based on prospective clinical trials. Moreover, we discuss a professional advancement for gastroenterologists in the diagnostic assessment of individuals who are cancer signal positive.

摘要

许多基于基因组的早期检测筛查测试正在研发中。这些测试有可能彻底改变当前的单器官筛查模式,尤其是在胃肠道癌症方面。在本综述中,我们根据前瞻性临床试验强调了这些基于基因组的早期检测测试的性能。此外,我们还讨论了胃肠病学家在对癌症信号呈阳性的个体进行诊断评估方面的专业进展。

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Genomic-Based Early Detection Screening: A Literature Review of Prospective Trials and Emerging Strategies for Gastrointestinal Cancers.基于基因组的早期检测筛查:胃肠道癌症前瞻性试验及新兴策略的文献综述
Cureus. 2024 Sep 7;16(9):e68881. doi: 10.7759/cureus.68881. eCollection 2024 Sep.
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JCO Oncol Pract. 2023 Dec;19(12):1111-1115. doi: 10.1200/OP.23.00260. Epub 2023 Oct 18.
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本文引用的文献

1
Improving Noninvasive Colorectal Cancer Screening.改善非侵入性结直肠癌筛查
N Engl J Med. 2024 Mar 14;390(11):1045-1046. doi: 10.1056/NEJMe2400366.
2
Next-Generation Multitarget Stool DNA Test for Colorectal Cancer Screening.用于结直肠癌筛查的下一代多靶点粪便 DNA 检测。
N Engl J Med. 2024 Mar 14;390(11):984-993. doi: 10.1056/NEJMoa2310336.
3
A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening.基于无细胞游离 DNA 的血液检测用于结直肠癌筛查。
N Engl J Med. 2024 Mar 14;390(11):973-983. doi: 10.1056/NEJMoa2304714.
4
Cancer statistics, 2024.2024年癌症统计数据。
CA Cancer J Clin. 2024 Jan-Feb;74(1):12-49. doi: 10.3322/caac.21820. Epub 2024 Jan 17.
5
The presenting symptom signatures of incident cancer: evidence from the English 2018 National Cancer Diagnosis Audit.首发癌症症状特征:来自 2018 年英国国家癌症诊断审计的证据。
Br J Cancer. 2024 Feb;130(2):297-307. doi: 10.1038/s41416-023-02507-4. Epub 2023 Dec 6.
6
Multicancer Early Detection Tests: An Overview of Early Results From Prospective Clinical Studies and Opportunities for Oncologists.多癌早期检测测试:前瞻性临床研究的早期结果概述及肿瘤学家面临的机遇
JCO Oncol Pract. 2023 Dec;19(12):1111-1115. doi: 10.1200/OP.23.00260. Epub 2023 Oct 18.
7
Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study.基于血液的多种癌症早期检测(PATHFINDER):一项前瞻性队列研究。
Lancet. 2023 Oct 7;402(10409):1251-1260. doi: 10.1016/S0140-6736(23)01700-2.
8
The aggregate value of cancer screenings in the United States: full potential value and value considering adherence.美国癌症筛查的总价值:充分潜力价值和考虑依从性的价值。
BMC Health Serv Res. 2023 Aug 7;23(1):829. doi: 10.1186/s12913-023-09738-4.
9
Editorial: Reviews in gastrointestinal cancers.社论:胃肠道癌症综述
Front Oncol. 2023 Jul 18;13:1252665. doi: 10.3389/fonc.2023.1252665. eCollection 2023.
10
Multi-cancer early detection test in symptomatic patients referred for cancer investigation in England and Wales (SYMPLIFY): a large-scale, observational cohort study.英国和威尔士因癌症检查而转诊的有症状患者的多癌早期检测试验(SYMPLIFY):一项大规模观察性队列研究
Lancet Oncol. 2023 Jul;24(7):733-743. doi: 10.1016/S1470-2045(23)00277-2. Epub 2023 Jun 20.