乙醇与亮氨酸氧化——I. 大鼠体内亮氨酸的氧化

Ethanol and leucine oxidation--I. Leucine oxidation by the rat in vivo.

作者信息

Ward L C, Carrington L E, Daly R

出版信息

Int J Biochem. 1985;17(2):187-93. doi: 10.1016/0020-711x(85)90113-2.

Abstract

The effect of ethanol upon the oxidation of leucine by the rat in vivo was determined. The rate of leucine oxidation was not significantly altered by chronic administration of ethanol (20% v/v solution as drinking water for 28 days). Ethanol administered acutely (8 g kg 0.73) significantly decreased leucine oxidation by the rat in vivo. This decrease appeared to be independent of a more general depression of oxidation metabolism. Decrease in leucine oxidation by ethanol is discussed in relation to the regulation of tissue leucine pool sizes in vivo.

摘要

测定了乙醇对大鼠体内亮氨酸氧化的影响。长期给予乙醇（20% v/v溶液作为饮用水，持续28天），亮氨酸氧化速率没有显著改变。急性给予乙醇（8 g kg⁻⁰.⁷³）显著降低了大鼠体内亮氨酸的氧化。这种降低似乎与氧化代谢的更普遍抑制无关。本文结合体内组织亮氨酸池大小的调节，讨论了乙醇导致亮氨酸氧化减少的情况。