Robinson Sarah E, Varman Rahul
Plastic and Reconstructive Surgery, Creighton University School of Medicine, Omaha, USA.
Cureus. 2024 Aug 9;16(8):e66531. doi: 10.7759/cureus.66531. eCollection 2024 Aug.
A 38-year-old woman with rheumatoid arthritis treated with etanercept presented with complaints of ear pain. Over four days, the pain progressed to a vesicular rash and then facial nerve paralysis. The patient was diagnosed with Ramsay Hunt syndrome (RHS), a reactivation of the varicella zoster virus that specifically affects the seventh cranial nerve (CN VII). Etanercept is an anti-tumor necrosis factor (anti-TNF) agent that has known immunosuppressive effects. RHS occurs more commonly in immunocompromised states, such as the one induced by etanercept. To the best of our knowledge, this is one of the first reported cases of RHS with etanercept treatment.
一名38岁接受依那西普治疗的类风湿关节炎女性患者出现耳痛症状。在四天时间里，疼痛发展为水疱疹，随后出现面神经麻痹。该患者被诊断为拉姆齐·亨特综合征（RHS），这是水痘带状疱疹病毒的再激活，特别影响第七颅神经（CN VII）。依那西普是一种抗肿瘤坏死因子（抗TNF）药物，已知具有免疫抑制作用。RHS在免疫功能低下状态下更常见，比如依那西普诱导的这种状态。据我们所知，这是首批报道的依那西普治疗引发RHS的病例之一。
