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一名13岁女性的髓母细胞瘤:一份综合病例报告。

Medulloblastoma in a 13-Year-Old Female: A Comprehensive Case Report.

作者信息

Ansari Khizer, Gaidhane Shilpa A, Parihar Pratapsingh, Saifi Iram, Saifi Azeem I

机构信息

Medicine and Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

Epidemiology and Public Health, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

出版信息

Cureus. 2024 Aug 7;16(8):e66359. doi: 10.7759/cureus.66359. eCollection 2024 Aug.

DOI:10.7759/cureus.66359
PMID:39246989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11379423/
Abstract

The majority of children's brain cancers are posterior fossa tumours, which include brainstem gliomas, medulloblastomas (MBs), juvenile pilocytic astrocytomas, and ependymomas. This report details a 13-year-old female presenting with headache, nausea, and ataxia. With typical magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) results, the MRI indicated a solid lesion in the fourth ventricle, producing obstructive hydrocephalus. Pilocytic astrocytoma, ependymoma, MB, and other conditions are examples of differential diagnoses. In addition to underscoring the need for early intervention to enhance prognosis and outcomes for paediatric patients with posterior fossa tumours, the case highlights the vital role that sophisticated imaging plays in early detection and therapy.

摘要

大多数儿童脑癌是后颅窝肿瘤,包括脑干胶质瘤、髓母细胞瘤(MBs)、青少年毛细胞型星形细胞瘤和室管膜瘤。本报告详细介绍了一名13岁女性,她出现头痛、恶心和共济失调症状。根据典型的磁共振成像(MRI)和磁共振波谱(MRS)结果,MRI显示第四脑室有一个实性病变,导致梗阻性脑积水。毛细胞型星形细胞瘤、室管膜瘤、MB及其他病症均为鉴别诊断的例子。该病例除了强调早期干预对改善后颅窝肿瘤患儿预后和治疗结果的必要性外,还凸显了精密成像在早期检测和治疗中所起的关键作用。

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本文引用的文献

1
The 2021 WHO Classification of Tumors of the Central Nervous System: a summary.2021 年世卫组织中枢神经系统肿瘤分类:概述。
Neuro Oncol. 2021 Aug 2;23(8):1231-1251. doi: 10.1093/neuonc/noab106.
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Pediatric Brain Tumor Genetics: What Radiologists Need to Know.小儿脑肿瘤遗传学:放射科医生需要了解的知识。
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Comparing children and adults with medulloblastoma: a SEER based analysis.儿童与成人髓母细胞瘤的比较:基于监测、流行病学和最终结果(SEER)的分析
Oncotarget. 2018 Jul 10;9(53):30189-30198. doi: 10.18632/oncotarget.23773.
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MRI surrogates for molecular subgroups of medulloblastoma.髓母细胞瘤分子亚组的MRI替代指标
AJNR Am J Neuroradiol. 2014 Jul;35(7):1263-9. doi: 10.3174/ajnr.A3990. Epub 2014 May 15.
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Evaluation of apparent diffusion coefficient thresholds for diagnosis of medulloblastoma using diffusion-weighted imaging.利用扩散加权成像评估髓母细胞瘤诊断的表观扩散系数阈值
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Molecular subgroups of medulloblastoma: the current consensus.髓母细胞瘤的分子亚型:当前共识。
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Quantitative diffusion-weighted and dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging analysis of T2 hypointense lesion components in pediatric diffuse intrinsic pontine glioma.儿童弥漫性内在脑桥胶质瘤 T2 低信号病灶成分的定量扩散加权和动态磁敏感对比增强灌注 MR 成像分析。
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Imaging of ependymomas: MRI and CT.室管膜瘤的影像学检查:磁共振成像(MRI)和计算机断层扫描(CT)
Childs Nerv Syst. 2009 Oct;25(10):1203-13. doi: 10.1007/s00381-009-0878-7. Epub 2009 Apr 10.