Damborg Peter, Allerton Fergus, Bousquet-Mélou Alain, Britt Chantal, Cagnardi Petra, Carmo Luis Pedro, Cvetkovikj Iskra, Erhard Marcel, Heuvelink Annet, Jessen Lisbeth Rem, Overesch Gudrun, Pelligand Ludovic, Gómez Raja Jonathan, Scahill Karolina, Timofte Dorina, Vale Ana P, Veldman Kees, Broens Els M
Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, 1870, Denmark.
Willows Veterinary Centre and Referral Service, Solihull, B90 4NH, UK.
Open Res Eur. 2024 Sep 24;4:170. doi: 10.12688/openreseurope.18016.1. eCollection 2024.
The global antimicrobial resistance crisis has been the driver of several international strategies on antimicrobial stewardship. For their implementation at the field level, the veterinary sector encounters several specific challenges and in particular: (i) a shortage of experts in key disciplines related to antimicrobial stewardship, (ii) a lack of evidence-based antimicrobial treatment guidelines, and (iii) inferior diagnostic tests available compared to human medicine. The present white paper describes how the COST Action ENOVAT (the European Network for Optimization of Veterinary Antimicrobial Treatment, CA18217), comprising 332 persons from 51 countries, worked towards solutions to these challenges. Initially, surveys were conducted to explore the present state in Europe in terms of existing antimicrobial use guidelines and microbiology practices performed. Concurrently, various research activities were launched to optimize diagnostics, including development of epidemiological cut-offs, clinical breakpoints and matrix-assisted laser desorption ionization time of flight mass spectrometry interpretive criteria. Also, guidelines drafting groups working towards evidence-based antimicrobial treatment guidelines for six conditions in food-producing and companion animals were established. The processes and outcomes, also in terms of capacity building, are summarized in this white paper where emphasis is placed on sustainability of the activities. Although several ENOVAT initiatives and spin-off projects will continue beyond the Action, we recommend that a new European veterinary research agenda is launched focusing on research and funding leading to long-term impacts on veterinary antimicrobial use.
全球抗菌药物耐药危机推动了多项关于抗菌药物管理的国际战略。为在实地层面实施这些战略，兽医部门面临若干具体挑战，特别是：（i）抗菌药物管理相关关键学科的专家短缺，（ii）缺乏循证抗菌治疗指南，以及（iii）与人类医学相比，可用的诊断检测手段较差。本白皮书描述了由来自51个国家的332人组成的COST行动ENOVAT（欧洲兽医抗菌治疗优化网络，CA18217）如何努力应对这些挑战。最初，开展了调查以探索欧洲在现有抗菌药物使用指南和微生物学实践方面的现状。同时，启动了各种研究活动以优化诊断，包括制定流行病学临界值、临床断点和基质辅助激光解吸电离飞行时间质谱解释标准。此外，还成立了指南起草小组，致力于为食用动物和伴侣动物的六种病症制定循证抗菌治疗指南。本白皮书总结了这些过程和成果，包括能力建设方面的成果，并强调了活动的可持续性。尽管若干ENOVAT倡议和衍生项目将在该行动结束后继续开展，但我们建议启动一项新的欧洲兽医研究议程，重点关注能够对兽医抗菌药物使用产生长期影响的研究和资金投入。
