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用协同纳米制剂使肿瘤相关巨噬细胞复极化，以逆转小鼠乳腺癌中的免疫抑制性肿瘤微环境用于癌症治疗。

repolarization of tumor-associated macrophages with synergic nanoformulation to reverse immunosuppressive TME in mouse breast cancer for cancer therapy.

作者信息

Luo Ruhua, Yue Zhongyu, Yang Qian, Zhang Honghua, Xie Tian, Wang Shuling, Tian Qingchang

机构信息

School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, China.

Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, China.

出版信息

J Pharm Anal. 2024 Aug;14(8):100941. doi: 10.1016/j.jpha.2024.01.009. Epub 2024 Feb 2.

DOI:10.1016/j.jpha.2024.01.009
PMID:39247487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11377137/
Abstract

Image 1.

摘要

图1。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/788a/11377137/da0054eb4af7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/788a/11377137/c7d48d0e5933/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/788a/11377137/1caaec295481/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/788a/11377137/da0054eb4af7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/788a/11377137/c7d48d0e5933/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/788a/11377137/1caaec295481/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/788a/11377137/da0054eb4af7/gr2.jpg

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本文引用的文献

1
PD-L1 expression on tumor-infiltrating immune cells is highly associated with M2 TAM and aggressive malignant potential in patients with resected non-small cell lung cancer.肿瘤浸润免疫细胞的 PD-L1 表达与 M2 TAM 高度相关，并与接受手术切除的非小细胞肺癌患者侵袭性恶性潜能相关。
Lung Cancer. 2019 Oct;136:136-144. doi: 10.1016/j.lungcan.2019.08.023. Epub 2019 Aug 31.
2
Molecular targets of β-elemene, a herbal extract used in traditional Chinese medicine, and its potential role in cancer therapy: A review.β-榄香烯，一种中药提取物的分子靶点及其在癌症治疗中的潜在作用：综述。
Biomed Pharmacother. 2019 Jun;114:108812. doi: 10.1016/j.biopha.2019.108812. Epub 2019 Apr 6.
3
T cell exclusion, immune privilege, and the tumor microenvironment.
T 细胞排斥、免疫特权和肿瘤微环境。
Science. 2015 Apr 3;348(6230):74-80. doi: 10.1126/science.aaa6204.
4
Tumor-associated macrophages: from mechanisms to therapy.肿瘤相关巨噬细胞：从机制到治疗
Immunity. 2014 Jul 17;41(1):49-61. doi: 10.1016/j.immuni.2014.06.010.