Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Cold Spring Harbor Laboratory, New York, NY 11724, USA. Department of Microbiology and Immunology, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical School, New York, NY 10065, USA.
Science. 2015 Apr 3;348(6230):74-80. doi: 10.1126/science.aaa6204.
Effective immunotherapy promotes the killing of cancer cells by cytotoxic T cells. This requires not only that cancer-specific T cells be generated, but also that these T cells physically contact cancer cells. The coexistence in some patients of cancer cells and T cells that recognize them indicates that tumors may exhibit the phenomenon of immune privilege, in which immunogenic tissue is protected from immune attack. Here, we review the evidence that stromal cells of the tumor microenvironment mediate this restriction by excluding T cells from the vicinity of cancer cells. Overcoming this T cell checkpoint may thus enable optimal immunotherapy.
有效的免疫疗法通过细胞毒性 T 细胞促进癌细胞的杀伤。这不仅需要产生针对癌症的 T 细胞，还需要这些 T 细胞与癌细胞进行物理接触。在一些患者中，癌细胞和识别它们的 T 细胞共存，这表明肿瘤可能表现出免疫特权现象，即免疫原性组织免受免疫攻击。在这里，我们回顾了肿瘤微环境中的基质细胞通过将 T 细胞排除在癌细胞附近来介导这种限制的证据。因此，克服这种 T 细胞检查点可能使免疫疗法达到最佳效果。
