卡宾催化下2-吡喃酮的简便构建。
Facile construction of 2-pyrones under carbene catalysis.
作者信息
Yu Miao, Huang Jie, Zhu Haibin, Shi Dongping, Yang Weiqi, Liu Yingjie, Ji Yubin, Fu Zhenqian
机构信息
Engineering Research Center for Medicine, Ministry of Education, Harbin University of Commerce Harbin 150076 China
Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering & Institute of Advanced Materials, Nanjing Tech University 30 South Puzhu Road Nanjing 211816 China
出版信息
RSC Adv. 2024 Sep 6;14(39):28585-28595. doi: 10.1039/d4ra05596a. eCollection 2024 Sep 4.
2-Pyrones are valuable structural motifs in organic chemistry, found in numerous natural products and pharmaceuticals. The synthesis of these heterocycles has been significantly advanced by the application of N-Heterocyclic Carbene (NHC) catalysis. This review examines the recent advancements in NHC-catalyzed synthesis of 2-pyrones, highlighting key methodologies, mechanisms, and synthetic applications. NHC catalysis has revolutionized the synthesis of 2-pyrones, providing efficient, selective, and versatile methods for constructing these valuable heterocycles.
2-吡喃酮是有机化学中重要的结构单元，存在于众多天然产物和药物中。氮杂环卡宾（NHC）催化的应用显著推动了这些杂环化合物的合成。本文综述了NHC催化合成2-吡喃酮的最新进展，重点介绍了关键方法、机理及合成应用。NHC催化彻底改变了2-吡喃酮的合成方式，为构建这些重要杂环化合物提供了高效、选择性和通用的方法。
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