Luo Cong, Xu Xinyi, Xu Jianfeng, Chen Xingkuan
Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Department of Chemistry, Jinan University, Guangzhou 510632, China.
Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Org Biomol Chem. 2022 Dec 7;20(47):9298-9301. doi: 10.1039/d2ob01859d.
An NHC-catalyzed [3 + 3] annulation reaction between α-bromo enals and 2-chlorocyclohexane-1,3-diones was developed for the rapid and efficient synthesis of various 4,5,6-trisubstituted α-pyrones, which are core structures in numerous natural products and synthetic bioactive molecules, in generally good to excellent yields.
开发了一种由国家卫生健康委员会（NHC）催化的α-溴代烯醛与2-氯环己烷-1,3-二酮之间的[3 + 3]环化反应，用于快速高效地合成各种4,5,6-三取代的α-吡喃酮，这些化合物是众多天然产物和合成生物活性分子的核心结构，产率普遍良好至优异。
