危重症患者优化氧疗的系统评价与个体参与者数据荟萃分析方案
Protocol for a systematic review and individual participant data meta-analysis of optimizing oxygen therapy in critically ill patients.
作者信息
Yang Xiaobo, Ouyang Yaqi, Xu Jiqian, Shang You
机构信息
Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
Front Med (Lausanne). 2024 Aug 23;11:1356557. doi: 10.3389/fmed.2024.1356557. eCollection 2024.
BACKGROUND
Oxygen therapy is a cornerstone treatment of critically ill patients in the intensive care unit (ICU). Whether lower oxygenation therapy brings superior survival outcomes to higher oxygenation therapy is unknown.
METHODS
We will search electronic databases: PubMed, Embase, Web of Science, the Cochrane Central Register of Controlled Trials (CENTRAL), International Clinical Trials Registry Platform (ICTRP), and ClinicalTrials.gov from inception to 1 January 2024. Two authors will independently screen for all eligible clinical studies. Emails will be sent for individual participant data. The statistical analyses will be conducted using STATA 15.0 software.
RESULTS
We will evaluate the efficacy of lower oxygenation therapy compared with higher oxygenation therapy based on individual participant data.
CONCLUSION
This study will offer clinical evidence for oxygen therapy in ICU patients.
背景
氧疗是重症监护病房（ICU）中危重症患者的基础治疗方法。较低氧合治疗是否比高氧合治疗带来更好的生存结局尚不清楚。
方法
我们将检索电子数据库：从数据库建立至2024年1月1日的PubMed、Embase、科学网、Cochrane对照试验中心注册库（CENTRAL）、国际临床试验注册平台（ICTRP）和ClinicalTrials.gov。两名作者将独立筛选所有符合条件的临床研究。将通过电子邮件获取个体参与者数据。将使用STATA 15.0软件进行统计分析。
结果
我们将基于个体参与者数据评估较低氧合治疗与较高氧合治疗相比的疗效。
结论
本研究将为ICU患者的氧疗提供临床证据。
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