牙周炎患病率与生物衰老加速：来自2009 - 2014年美国国家健康与营养检查调查（NHANES）及孟德尔随机化研究的见解

Periodontitis prevalence and acceleration of biological aging: Insights from NHANES 2009-2014 and Mendelian randomization study.

作者信息

Song Lin, Wang Yifan, Zheng Qiwen, Li Wenjing

机构信息

Beijing Institute of Dental Research, Beijing Stomatological Hospital, Capital Medical University, Beijing, China.

Department of Periodontology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China.

出版信息

J Periodontal Res. 2025 Apr;60(4):350-360. doi: 10.1111/jre.13345. Epub 2024 Sep 9.

DOI:10.1111/jre.13345

PMID:39248183

Abstract

AIM

This study aimed to investigate the association of periodontitis with biological aging and to assess potential causality using Mendelian randomization (MR).

METHODS

A cross-sectional study with 9558 participants from the National Health and Nutrition Examination Survey (2009-2014) was conducted. Age acceleration (BioAgeAccel and PhenoAgeAccel) was calculated from clinical biomarkers and their discrepancies with chronological age. Two-sample MR analysis was performed using data from a large-scale genome-wide association study and UK Biobank.

RESULTS

Periodontitis was associated with increased biological aging, with 0.57-year (95% CI: 0.28-0.86, p < .001) increases in BioAgeAccel and 0.41-year (95% CI: 0.04-0.78, p = .034) increases in PhenoAgeAccel. Subgroup analysis found significantly stronger associations in males for BioAgeAccele (P = .006), and pronounced associations in young adults (p = .023), individuals with normal body mass index (p = .015), and current smokers (p = .016) for PehonAgeAccel. MR analysis did not provide strong evidence for a causal effect of periodontitis on biological aging (BioAgeAccel: IVW β = 0.008, 95% CI: -0.018 to 0.034, p = .553 and PhenoAgeAccel: IVW β = 0.016, 95% CI: -0.042 to 0.074, p = .585).

CONCLUSION

This study identified the association of periodontitis and its severity with accelerated aging, suggesting periodontal health could be a possible method in personalized preventive and therapeutic strategies of biological aging.

摘要

目的

本研究旨在调查牙周炎与生物衰老之间的关联，并使用孟德尔随机化（MR）评估潜在的因果关系。

方法

对来自国家健康与营养检查调查（2009 - 2014年）的9558名参与者进行了横断面研究。根据临床生物标志物及其与实际年龄的差异计算年龄加速（生物年龄加速和表型年龄加速）。使用来自大规模全基因组关联研究和英国生物银行的数据进行两样本MR分析。

结果

牙周炎与生物衰老增加相关，生物年龄加速增加0.57年（95%可信区间：0.28 - 0.86，p <.001），表型年龄加速增加0.41年（95%可信区间：0.04 - 0.78，p = 0.034）。亚组分析发现，男性中生物年龄加速的关联显著更强（P = 0.006），而在年轻人（p = 0.023）、体重指数正常的个体（p = 0.015）和当前吸烟者（p = 0.016）中，表型年龄加速的关联更为明显。MR分析没有提供强有力的证据证明牙周炎对生物衰老有因果效应（生物年龄加速：逆方差加权β = 0.008，95%可信区间：-0.018至0.034，p = 0.553；表型年龄加速：逆方差加权β = 0.016，95%可信区间：-0.042至0.074，p = 0.585）。