花生四烯酸会促进大鼠实验性慢性骨髓炎的发展。
Arachidonic acid facilitates experimental chronic osteomyelitis in rats.
作者信息
Rissing J P, Buxton T B, Fisher J, Harris R, Shockley R K
出版信息
Infect Immun. 1985 Jul;49(1):141-4. doi: 10.1128/iai.49.1.141-144.1985.
Abstract
Arachidonic acid was used as a facilitating agent in experimental rat Staphylococcus aureus osteomyelitis and compared with the more commonly used agent, sodium morrhuate. The injection of arachidonic acid or sodium morrhuate and S. aureus into rat tibiae caused increased quantitative bacterial bone counts, gross bone pathology, roentgenographic changes, and weight loss. The doses required to produce these changes appeared to be lower for arachidonic acid.
摘要
花生四烯酸被用作实验性大鼠金黄色葡萄球菌骨髓炎的促进剂，并与更常用的剂鱼肝油酸钠进行比较。将花生四烯酸或鱼肝油酸钠与金黄色葡萄球菌注射到大鼠胫骨中会导致细菌骨定量计数增加、肉眼可见的骨病理学变化、X线变化和体重减轻。产生这些变化所需的剂量对于花生四烯酸似乎更低。
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