Liu Lingli, Xiang Chengli, Pan Changduo, Yu Jin-Tao
School of Petrochemical Engineering, Changzhou University, Changzhou 213164, P. R. China.
School of Chemistry and Chemical Engineering, Jiangsu University of Technology, Changzhou 213001, P. R. China.
Chem Commun (Camb). 2024 Sep 24;60(77):10764-10767. doi: 10.1039/d4cc03384a.
A photocatalytic trifluoromethylation/cyclization reaction of -allyl and -homoallyl aldehyde hydrazones with trifluoromethyl thianthrenium triflate was developed for the synthesis of trifluoromethylated dihydropyrazoles and tetrahydropyridazines. Besides, PhI(OCCHF) was employed to realize the construction of difluoromethylated dihydropyrazoles and tetrahydropyridazines. These protocols exhibit a broad substrate scope and good functional group tolerance.
开发了一种用三氟甲硫代蒽三氟甲磺酸盐对烯丙基和高烯丙基醛腙进行光催化三氟甲基化/环化反应，用于合成三氟甲基化二氢吡唑和四氢哒嗪。此外，使用PhI(OCCHF)实现了二氟甲基化二氢吡唑和四氢哒嗪的构建。这些方法具有广泛的底物范围和良好的官能团耐受性。
