Aronoff S C, Klinger J D
J Antimicrob Chemother. 1985 May;15(5):545-9. doi: 10.1093/jac/15.5.545.
Cefpiramide (HR-810), ceftazidime, piperacillin, ticarcillin, and aztreonam were tested against tobramycin-sensitive and -resistant strains of Pseudomonas aeruginosa and tobramycin/amikacin-resistant isolates of Ps. cepacia recovered from the sputum of patients with cystic fibrosis. Against Ps. aeruginosa, none of the drugs inhibited 90% of the test strains at levels of less than 128 mg/l. Median minimal, inhibitory concentrations (MIC50) for all of the beta-lactam agents were lower for tobramycin-sensitive versus tobramycin-resistant isolates of Ps. aeruginosa. Ceftazidime was the most effective agent against Ps. cepacia. Aminoglycoside-resistance appears to be associated with significant beta-lactam resistance in Ps. aeruginosa isolated from the sputum of patients with cystic fibrosis.
对从囊性纤维化患者痰液中分离出的对妥布霉素敏感和耐药的铜绿假单胞菌菌株以及对妥布霉素/阿米卡星耐药的洋葱伯克霍尔德菌分离株，进行了头孢匹胺（HR - 810）、头孢他啶、哌拉西林、替卡西林和氨曲南的测试。对于铜绿假单胞菌，在低于128mg/l的浓度下，没有一种药物能抑制90%的测试菌株。对于铜绿假单胞菌，所有β - 内酰胺类药物对妥布霉素敏感菌株的中位最小抑菌浓度（MIC50）低于对妥布霉素耐药菌株。头孢他啶是对抗洋葱伯克霍尔德菌最有效的药物。在从囊性纤维化患者痰液中分离出的铜绿假单胞菌中，氨基糖苷类耐药似乎与显著的β - 内酰胺类耐药相关。
