给予抗白细胞介素2受体单克隆抗体可延长小鼠心脏移植的存活时间。
Administration of an anti-interleukin 2 receptor monoclonal antibody prolongs cardiac allograft survival in mice.
作者信息
Kirkman R L, Barrett L V, Gaulton G N, Kelley V E, Ythier A, Strom T B
出版信息
J Exp Med. 1985 Jul 1;162(1):358-62. doi: 10.1084/jem.162.1.358.
Abstract
Administration of the monoclonal antibody M7/20, which binds to the murine interleukin-2 (IL) receptor, significantly prolongs cardiac allograft survival in two H-2-incompatible strain combinations of inbred mice. The results support the important role of the IL-2 receptor in the mechanism of graft rejection, and suggest its suitability as a target for immunosuppressive therapy.
摘要
与小鼠白细胞介素-2（IL）受体结合的单克隆抗体M7/20的给药，显著延长了两种近交系小鼠H-2不相容品系组合中心脏同种异体移植的存活时间。这些结果支持了IL-2受体在移植排斥机制中的重要作用，并表明其适合作为免疫抑制治疗的靶点。
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