Mäkinen K K, Hämäläinen M M
J Nutr. 1985 Jul;115(7):890-9. doi: 10.1093/jn/115.7.890.
The effect of feeding high amounts of polyols on rat metabolism was studied. Adult male rats were fed the basal diet or the same diet to which had been added either galactitol, mannitol or xylitol for 8 wk (final polyol level 200 g/kg diet). Although all three polyols retarded the growth rate of the animals, the polyols were well tolerated. The four experimental groups did not differ significantly (P greater than 0.01) in the following analyses: blood lactic acid and serum transaminases, amylase, lactate dehydrogenase, triglycerides, insulin, glucagon and corticosterone. Compared to rats fed the basal diet, galactitol rats had higher blood hemoglobin levels (P less than 0.01); those fed galactitol or mannitol had lower blood glucose (P less than 0.001 and P less than 0.01, respectively), and those fed mannitol had higher blood pyruvic acid (P less than 0.01). Rats fed any of the polyols had lower serum total cholesterol and liver ascorbic acid (P less than 0.001) than control rats. Rats fed mannitol had higher liver glycogen levels (P less than 0.001) than control rats. Irrespective of the structural differences between the pentitol and the hexitols, a number of common metabolic effects were found. The proposed mechanisms of these effects include 1) the slow absorption and the rapid intraluminal metabolism of the polyols and 2) the similar handling of these polyols in the liver by a dehydrogenase.
研究了大量喂食多元醇对大鼠新陈代谢的影响。成年雄性大鼠被喂食基础日粮或添加了半乳糖醇、甘露醇或木糖醇的相同日粮，持续8周（最终多元醇水平为200 g/kg日粮）。尽管所有三种多元醇都延缓了动物的生长速度，但它们的耐受性良好。在以下分析中，四个实验组没有显著差异（P大于0.01）：血乳酸、血清转氨酶、淀粉酶、乳酸脱氢酶、甘油三酯、胰岛素、胰高血糖素和皮质酮。与喂食基础日粮的大鼠相比，半乳糖醇组大鼠的血红蛋白水平更高（P小于0.01）；喂食半乳糖醇或甘露醇的大鼠血糖较低（分别为P小于0.001和P小于0.01），而喂食甘露醇的大鼠丙酮酸水平较高（P小于0.01）。喂食任何一种多元醇的大鼠血清总胆固醇和肝脏抗坏血酸水平均低于对照大鼠（P小于0.001）。喂食甘露醇的大鼠肝脏糖原水平高于对照大鼠（P小于0.001）。无论戊糖醇和己糖醇之间的结构差异如何，都发现了一些共同的代谢效应。这些效应的推测机制包括：1）多元醇吸收缓慢和管腔内代谢迅速；2）肝脏中一种脱氢酶对这些多元醇的处理方式相似。
