Mattila P T, Svanberg M J, Mäkinen K K, Knuuttila M L
Institute of Dentistry, University of Oulu, Finland.
J Nutr. 1996 Jul;126(7):1865-70. doi: 10.1093/jn/126.7.1865.
The aim of the present study was to compare the ability of four dietary polyols to reduce bone resorption. Urinary excretion of 3H radioactivity from [3H]tetracycline-prelabeled rats was used as a marker of bone resorption. After prelabeling, the rats were divided randomly into five groups of 10, and fed for 1 mo a nonpurified diet that was supplemented in four groups with either xylitol, sorbitol, D-mannitol or erythritol, respectively, to give a polyol concentration of 1 mol/kg. Xylitol (42%), sorbitol (44%) and to a lesser degree D-mannitol (23%) decreased the excretion of 3H relative to the basal diet. The erythritol group, however, did not differ from the controls. Sorbitol caused continuous diarrhea, whereas in the other groups, intestinal adaptation took place during the 1st wk of polyol feeding. In conclusion, dietary xylitol, sorbitol and to a lesser degree D-mannitol supplementations in rats retard bone resorption, whereas dietary erythritol has no effect.
本研究的目的是比较四种膳食多元醇减少骨吸收的能力。以[³H]四环素预标记大鼠的³H放射性尿排泄量作为骨吸收的标志物。预标记后，将大鼠随机分为五组，每组10只，给其中四组分别喂食添加了木糖醇、山梨醇、D - 甘露醇或赤藓糖醇的非纯化日粮，使多元醇浓度达到1 mol/kg，持续喂养1个月。与基础日粮相比，木糖醇（42%）、山梨醇（44%）以及程度稍低的D - 甘露醇（23%）均降低了³H的排泄量。然而，赤藓糖醇组与对照组无差异。山梨醇导致持续性腹泻，而在其他组中，多元醇喂养的第1周出现了肠道适应性变化。总之，大鼠日粮中添加木糖醇、山梨醇以及程度稍低的D - 甘露醇可延缓骨吸收，而日粮中添加赤藓糖醇则无此作用。
