Kunert J
J Basic Microbiol. 1985;25(2):111-8. doi: 10.1002/jobm.3620250207.
The dermatophyte Microsporum gypseum was cultivated on a glucose-arginine medium supplemented with five strongly acidic derivatives of cysteine (L-cysteine sulfinic acid, L-cysteic acid, L-serine-O-sulfate and taurine at a concentration of 5 mmol/l, and L-S-sulfocysteine at a concentration of 2.5 mmol/l). The addition of these substances did not stimulate the growth as compared with the control containing 0.5 mmol/l cystine. Cysteine sulfinic acid and cysteic acid showed rather inhibitory effects. A strong inhibition of the growth was caused by the presence of serine sulfate. During the growth, all substances investigated were gradually consumed and utilized not only as a source of sulfur but of nitrogen and carbon as well. Cysteine sulfinic acid and S-sulfocysteine were utilized most rapidly. Cysteic acid was also rapidly utilized but after a certain adaptation. Taurine was utilized slowly and serine sulfate very slowly. Excess sulfur contained in the substances used was excreted into the medium in the form of sulfate. Sulfate excretion was most rapid with cysteine sulfinic acid and slowest with taurine. With cysteine sulfinic acid, S-sulfocysteine and cysteic acid, small amounts of sulfite were found in the medium. The results obtained are in accordance with the presumption that cysteine sulfinic acid (but not cysteic acid and taurine) is an intermediate of cysteine catabolism in dermatophytes.
皮肤癣菌石膏样小孢子菌在添加了五种强酸性半胱氨酸衍生物的葡萄糖 - 精氨酸培养基上培养（L - 半胱氨酸亚磺酸、L - 半胱氨酸磺酸、L - 丝氨酸 - O - 硫酸盐和牛磺酸浓度为5 mmol/l，L - S - 磺基半胱氨酸浓度为2.5 mmol/l）。与含有0.5 mmol/l胱氨酸的对照相比，添加这些物质并未刺激其生长。半胱氨酸亚磺酸和半胱氨酸磺酸表现出相当的抑制作用。丝氨酸硫酸盐的存在对生长有强烈抑制作用。在生长过程中，所有研究的物质不仅作为硫源，而且作为氮源和碳源逐渐被消耗和利用。半胱氨酸亚磺酸和S - 磺基半胱氨酸的利用速度最快。半胱氨酸磺酸在经过一定适应后也被迅速利用。牛磺酸的利用速度较慢，丝氨酸硫酸盐的利用速度非常慢。所用物质中所含的过量硫以硫酸盐的形式排泄到培养基中。半胱氨酸亚磺酸的硫酸盐排泄最快，牛磺酸最慢。在含有半胱氨酸亚磺酸、S - 磺基半胱氨酸和半胱氨酸磺酸的培养基中发现了少量亚硫酸盐。所得结果符合以下推测：半胱氨酸亚磺酸（而非半胱氨酸磺酸和牛磺酸）是皮肤癣菌中半胱氨酸分解代谢的中间产物。
