Anderson G H, Ashley D V, Jones J D
J Nutr. 1976 Aug;106(8):1108-14. doi: 10.1093/jn/106.8.1108.
Three experiments were conducted to test the ability of weanling rats to utilize the oxidized forms of the sulfur amino acids methionine and cysteine for growth. In the first two experiments, diets were fed which contained graded levels of methionine, methionine sulfoxide and methionine sulfone. The third experiment included a comparison of two dietary levels of cysteine and cysteic acid. The 2 week weight gain and food consumption data indicated that methionine sulfoxide was utilized for growth with only 60% of the efficiency of that achieved by rats fed methionine. Methionine sulfone was not utilized for growth. Analysis of plasma sulfur amino acids showed that the rat has a limited capacity to utilize methionine sulfoxide by effecting its reduction to methionine. Cysteic acid did not support weight gain. This amino acid appeared to be rapidly catabolized to taurine. It was concluded that methionine sulfone and cysteic acid cannot be utilized by the weanling rat. Methionine sulfoxide cannot fully meet the dietary requirement of the rat methionine because of its limited capacity to reduce this amino acid.
进行了三项实验，以测试断奶大鼠利用含硫氨基酸蛋氨酸和半胱氨酸的氧化形式来促进生长的能力。在前两项实验中，所喂食的日粮含有不同水平的蛋氨酸、蛋氨酸亚砜和蛋氨酸砜。第三个实验比较了两种日粮水平的半胱氨酸和半胱磺酸。两周的体重增加和食物消耗数据表明，蛋氨酸亚砜可用于生长，但其效率仅为喂食蛋氨酸的大鼠的60%。蛋氨酸砜不能用于生长。血浆含硫氨基酸分析表明，大鼠通过将蛋氨酸亚砜还原为蛋氨酸来利用它的能力有限。半胱磺酸不能支持体重增加。这种氨基酸似乎迅速分解代谢为牛磺酸。得出的结论是，断奶大鼠不能利用蛋氨酸砜和半胱磺酸。由于大鼠还原这种氨基酸的能力有限，蛋氨酸亚砜不能完全满足大鼠对蛋氨酸的日粮需求。
