Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O.Box:14155-6117, Tehran, Iran.
Victorian Heart Institute, Monash university, Melbourne, Australia.
BMC Womens Health. 2024 Sep 9;24(1):497. doi: 10.1186/s12905-024-03260-3.
Migraine is an episodic disorder and a frequent form of headache. An impaired balance between free radical production and an impaired antioxidant defense system leading to oxidative damage may play a major role in migraine etiology. We sought to investigate whether dietary antioxidant quality score (DAQS) is associated with migraine intensity and frequency among women suffering from migraine.
This cross-sectional study was conducted on 265 women. The data related to anthropometric measures and dietary intake were collected. DAQS score was calculated based on FFQ (food frequency questionnaire) vs. the reference daily intake (RDI) quantity. To measure migraine intensity, the migraine disability assessment questionnaire (MIDAS) and visual analog scale (VAS) were used. The frequency of headaches was defined as the days the participants had headaches in the last month and a 30-day headache diary was used.
The results of the study demonstrated that VAS, MIDAS, and frequency of headaches were reduced significantly from the low DAQS (poor quality of antioxidants) to high DAQS (high quality of antioxidants) after adjusting covariates. Also, multinomial regression showed there was an inverse association between higher DAQS and the frequency of headaches. In the adjusted model, subjects with the higher DAQS were 69% less likely to have moderate migraine disability, compared with those with the lower DAQS. Linear regression showed, there was an inverse association between vitamin C intake and the grades of pain severity.َAlso in a crude model, a negative association was found between vitamin E and the frequency of headaches.
In conclusion, Participants with higher DAQS had lower migraine intensity and headache frequency. In addition, the consumption of vitamin C may potentially associate with decreasing the severity of headaches. Dietary antioxidants should be monitored closely in individuals suffering from migraine.
偏头痛是一种发作性疾病，也是一种常见的头痛类型。自由基生成和抗氧化防御系统受损之间的平衡失调导致氧化损伤，可能在偏头痛发病机制中起主要作用。我们试图研究女性偏头痛患者的膳食抗氧化质量评分（DAQS）与偏头痛严重程度和频率之间是否存在关联。
这是一项横断面研究，共纳入了 265 名女性。收集了与人体测量指标和饮食摄入有关的数据。根据 FFQ（食物频率问卷）与参考日摄入量（RDI）的比值计算 DAQS 评分。使用偏头痛残疾评估问卷（MIDAS）和视觉模拟量表（VAS）来衡量偏头痛的严重程度。头痛频率定义为参与者在过去一个月中头痛的天数，并使用 30 天头痛日记进行评估。
研究结果表明，在校正了协变量后，从低 DAQS（抗氧化剂质量差）到高 DAQS（抗氧化剂质量高），VAS、MIDAS 和头痛频率均显著降低。多变量回归还显示，较高的 DAQS 与头痛频率呈负相关。在调整后的模型中，与低 DAQS 相比，高 DAQS 组发生中度偏头痛残疾的可能性降低了 69%。线性回归显示，维生素 C 摄入量与疼痛严重程度等级呈负相关。在原始模型中，维生素 E 与头痛频率呈负相关。
总之，DAQS 较高的参与者偏头痛严重程度和头痛频率较低。此外，维生素 C 的摄入可能与头痛严重程度的降低有关。在偏头痛患者中应密切监测膳食抗氧化剂。
