School of Psychology, Zhejiang Normal University, Jinhua, China.
Intelligent Laboratory of Child and Adolescent Mental Health and Crisis Intervention of Zhejiang Province, Zhejiang Normal University, Jinhua, China.
Medicine (Baltimore). 2024 Sep 6;103(36):e39572. doi: 10.1097/MD.0000000000039572.
Cognitive-behavioral intervention techniques are increasingly demonstrating their efficacy in preventing relapses and managing problems in patients with schizophrenia. There is still variation in its effectiveness for negative symptoms, such as mood-related symptoms and motivation to engage socially.
A systematic search was conducted in PubMed, Web of Science for English literature on cognitive-behavioral therapy (CBT) interventions in patients with schizophrenia. The search included randomized controlled trials and nonrandomized controlled trials. The search period extended from the inception of the databases to September 30, 2022. Two researchers independently performed quality assessment and data extraction based on predefined inclusion and exclusion criteria.
Discrepancies were resolved through discussion or consultation with a third researcher. Initially, 169 articles were retrieved through database searches and other means. After applying the inclusion and exclusion criteria, 10 randomized controlled studies were included in the final analysis. The intervention group comprised a total of 680 patients with schizophrenia, while the control group included 686 patients with schizophrenia. Meta-analysis results demonstrated a statistically significant difference in negative symptom reduction between the CBT intervention group (WMD = -1.19, 95% CI [-1.73, -0.66], P < .0001) and the control group.
We have analyzed the effectiveness of CBT based on our previous research, CBT was found to effectively improve negative symptoms in individuals diagnosed with schizophrenia.
认知行为干预技术在预防精神分裂症患者复发和处理问题方面的疗效日益显著。但其对情绪相关症状和社交参与动机等阴性症状的疗效仍存在差异。
我们在 PubMed 和 Web of Science 上对英文文献进行了系统检索，以查找针对精神分裂症患者的认知行为疗法 (CBT) 干预措施。检索包括随机对照试验和非随机对照试验。检索时间从数据库建立到 2022 年 9 月 30 日。两名研究人员根据预先设定的纳入和排除标准独立进行质量评估和数据提取。
通过讨论或与第三名研究人员协商解决了分歧。最初通过数据库搜索和其他方式检索到 169 篇文章。在应用纳入和排除标准后，最终有 10 项随机对照研究纳入了分析。干预组共有 680 例精神分裂症患者，对照组有 686 例精神分裂症患者。荟萃分析结果表明，CBT 干预组（WMD=-1.19，95%CI[-1.73，-0.66]，P<.0001）与对照组相比，在减轻阴性症状方面存在统计学显著差异。
我们根据之前的研究分析了 CBT 的有效性，发现 CBT 可有效改善精神分裂症患者的阴性症状。
