Priyamvada Richa, Ranjan Rupesh, Jha Gyanendra Kumar, Chaudhury Suprakash
Department of Psychiatry, Chirayu Medical College and Hospital, India.
Department of Psychiatry, Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India.
Ind Psychiatry J. 2021 Jul-Dec;30(2):249-254. doi: 10.4103/ipj.ipj_44_20. Epub 2021 Sep 8.
Patients with schizophrenia manifests a broad array of cognitive impairments, including impaired performance on measures reflecting attention, information processing, executive functions, memory, and language capabilities.
This study aims to assess neurocognitive deficits and their correlation with positive and negative symptoms in patients with schizophrenia.
Sample was collected from private clinic of Jabalpur, Bhopal, and Patna. Selection of sample was purposive sampling. The sample size consists of 60 diagnosed cases of schizophrenia on the basis of (International Classification of Diseases-10 [ICD-10] Diagnostic Criteria for Research criteria) and 30 normal controls. Annet's Hand Preference Battery was used to screen handedness and only right-handed male were included in this study. After screening according to inclusion and exclusion criteria, 60 diagnosed (ICD-10 criteria) schizophrenia patients were selected which was further divided into two groups on the basis of positive and negative syndrome scale, i.e. schizophrenia with positive and negative symptoms. Thirty matched normal controls having scores <2 scores on General Health Questionnaire-12 were selected for the study. After filling of sociodemographic details Luria-Nebraska Neuropsychological Battery (LNNB-I) was administered on both schizophrenia group and normal control.
Cognitive functions are severely impaired in schizophrenia compared to normal control and within schizophrenia groups negative schizophrenia had poor performance on LNNB-I than positive schizophrenia. Regarding the correlation of neurocognitive deficits, both schizophrenia groups were correlated but negative symptoms of schizophrenia were strongly correlated with neurocognitive deficits.
Cognitive functions are severely impaired in schizophrenia as compared to normal control and within schizophrenia groups, negative schizophrenia had poor performance on LNNB-I than positive schizophrenia. Regarding the correlation of neurocognitive deficits, both schizophrenias groups were correlated but negative symptoms of schizophrenia were strongly correlated with neurocognitive deficits.
精神分裂症患者表现出广泛的认知障碍，包括在反映注意力、信息处理、执行功能、记忆和语言能力的测量指标上表现受损。
本研究旨在评估精神分裂症患者的神经认知缺陷及其与阳性和阴性症状的相关性。
样本取自贾巴尔普尔、博帕尔和巴特那的私人诊所。样本选择为目的抽样。样本量包括60例根据（《国际疾病分类第10版[ICD - 10]研究诊断标准》）确诊的精神分裂症病例和30名正常对照。使用安尼特利手偏好量表筛选利手，本研究仅纳入右利手男性。根据纳入和排除标准进行筛选后，选择60例确诊（ICD - 10标准）的精神分裂症患者，根据阳性和阴性症状量表进一步分为两组，即伴有阳性和阴性症状的精神分裂症。选择30名在一般健康问卷 - 12上得分<2分的匹配正常对照进行研究。在填写社会人口学详细信息后，对精神分裂症组和正常对照组均进行了鲁利亚 - 内布拉斯加神经心理量表（LNNB - I）测试。
与正常对照相比，精神分裂症患者的认知功能严重受损，并且在精神分裂症组内，阴性症状的精神分裂症患者在LNNB - I上的表现比阳性症状的精神分裂症患者差。关于神经认知缺陷的相关性，两个精神分裂症组均存在相关性，但精神分裂症的阴性症状与神经认知缺陷密切相关。
与正常对照相比，精神分裂症患者的认知功能严重受损，并且在精神分裂症组内，阴性症状的精神分裂症患者在LNNB - I上的表现比阳性症状的精神分裂症患者差。关于神经认知缺陷的相关性，两个精神分裂症组均存在相关性，但精神分裂症的阴性症状与神经认知缺陷密切相关。
