Huang Chunyu, Liang Weipeng, Sun Yuying
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China.
Department of Endoscopy, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China.
Adv Lab Med. 2024 Apr 26;5(3):276-282. doi: 10.1515/almed-2023-0170. eCollection 2024 Sep.
To investigate the role of body mass index (BMI), serum lipid profile molecules and their derivative indexes in colorectal polyps.
A total of 352 individuals who underwent colonoscopy at our center were included in this retrospective analysis. Of these, 247 patients without evident abnormalities (control group), while 105 patients diagnosed with colorectal polyps (patient group). Serum lipid profile molecules and their derivative indexes were then compared between the two groups.
The patient group exhibited significantly higher levels of total cholesterol (TC) and apolipoprotein B (ApoB) compared to the control group (p<0.05). In males, the patient group displayed elevated levels of ApoB and ApoB/ApoA1 ratio compared to the control group (p<0.05). Additionally, the triglycerides (TG) and TG/high-density lipoprotein-cholesterol (HDL-C) ratios were significantly higher in the multiple polyps group than in the single polyp group (p<0.05). Furthermore, the HDL-C and HDL-C/ApoA1 ratio levels were higher in the adenomatous polyp group when compared to the non-adenomatous polyp group (p<0.05). Multiple logistic regression analysis indicated that total cholesterol (TC), TG, low-density lipoprotein-cholesterol (LDL-C), TC/HDL-C ratio, TG/HDL-C ratio and LDL-C/HDL-C ratio were risk factors for the occurrence of colorectal polyps (p<0.05). ROC curve analyses revealed that TC, ApoB, and ApoB/ApoA1 ratio were associated with colorectal polyps. No significant difference in BMI between the two groups (p>0.05).
The incidence and progression of colorectal polyps are linked to serum lipid molecules and their derivative indexes. Dyslipidemia may increase the risk of colorectal polyps, potentially leading to colorectal cancer (CRC).
探讨体重指数（BMI）、血脂谱分子及其衍生指标在大肠息肉中的作用。
本回顾性分析纳入了在我院中心接受结肠镜检查的352例患者。其中，247例患者无明显异常（对照组），105例患者被诊断为大肠息肉（患者组）。然后比较两组的血脂谱分子及其衍生指标。
与对照组相比，患者组的总胆固醇（TC）和载脂蛋白B（ApoB）水平显著更高（p<0.05）。在男性中，患者组的ApoB和ApoB/ApoA1比值水平高于对照组（p<0.05）。此外，多发息肉组的甘油三酯（TG）和TG/高密度脂蛋白胆固醇（HDL-C）比值显著高于单发息肉组（p<0.05）。此外，腺瘤性息肉组的HDL-C和HDL-C/ApoA1比值水平高于非腺瘤性息肉组（p<0.05）。多因素logistic回归分析表明，总胆固醇（TC）、TG、低密度脂蛋白胆固醇（LDL-C）、TC/HDL-C比值、TG/HDL-C比值和LDL-C/HDL-C比值是大肠息肉发生的危险因素（p<0.05）。ROC曲线分析显示，TC、ApoB和ApoB/ApoA1比值与大肠息肉有关。两组间BMI无显著差异（p>0.05）。
大肠息肉的发生和进展与血脂分子及其衍生指标有关。血脂异常可能增加大肠息肉的风险，潜在地导致结直肠癌（CRC）。
