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疱疹病毒生命周期中UL51蛋白的功能。

Functions of the UL51 protein during the herpesvirus life cycle.

作者信息

Liu Xiaolan, Wang Mingshu, Cheng Anchun, Yang Qiao, Tian Bin, Ou Xumin, Sun Di, He Yu, Wu Zhen, Zhao Xinxin, Wu Ying, Zhang Shaqiu, Huang Juan, Jia Renyong, Chen Shun, Liu Mafeng, Zhu Dekang

机构信息

Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, China.

Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, China.

出版信息

Front Microbiol. 2024 Aug 26;15:1457582. doi: 10.3389/fmicb.2024.1457582. eCollection 2024.

DOI:10.3389/fmicb.2024.1457582
PMID:39252835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11381400/
Abstract

The herpesvirus UL51 protein is a multifunctional tegument protein involved in the regulation of multiple aspects of the viral life cycle. This article reviews the biological characteristics of the UL51 protein and its functions in herpesviruses, including participating in the maintenance of the viral assembly complex (cVAC) during viral assembly, affecting the production of mature viral particles and promoting primary and secondary envelopment, as well as its positive impact on viral cell-to-cell spread (CCS) through interactions with multiple viral proteins and its key role in the proliferation and pathogenicity of the virus in the later stage of infection. This paper discusses how the UL51 protein participates in the life cycle of herpesviruses and provides new ideas for further research on UL51 protein function.

摘要

疱疹病毒UL51蛋白是一种多功能的包膜蛋白，参与病毒生命周期多个方面的调控。本文综述了UL51蛋白的生物学特性及其在疱疹病毒中的功能，包括在病毒组装过程中参与维持病毒组装复合体（cVAC）、影响成熟病毒颗粒的产生并促进一级和二级包膜化，以及通过与多种病毒蛋白相互作用对病毒细胞间传播（CCS）产生的积极影响及其在感染后期病毒增殖和致病性中的关键作用。本文探讨了UL51蛋白如何参与疱疹病毒的生命周期，并为进一步研究UL51蛋白的功能提供了新思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1105/11381400/b3bdbe94f96a/fmicb-15-1457582-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1105/11381400/1bd6148d10bc/fmicb-15-1457582-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1105/11381400/f82d327ec3d0/fmicb-15-1457582-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1105/11381400/b3bdbe94f96a/fmicb-15-1457582-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1105/11381400/1bd6148d10bc/fmicb-15-1457582-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1105/11381400/f82d327ec3d0/fmicb-15-1457582-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1105/11381400/b3bdbe94f96a/fmicb-15-1457582-g003.jpg

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Functions of the UL51 protein during the herpesvirus life cycle.疱疹病毒生命周期中UL51蛋白的功能。
Front Microbiol. 2024 Aug 26;15:1457582. doi: 10.3389/fmicb.2024.1457582. eCollection 2024.
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本文引用的文献

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Human cytomegalovirus deploys molecular mimicry to recruit VPS4A to sites of virus assembly.人巨细胞病毒利用分子模拟招募 VPS4A 到病毒组装部位。
PLoS Pathog. 2024 Jun 20;20(6):e1012300. doi: 10.1371/journal.ppat.1012300. eCollection 2024 Jun.
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Palmitoylation of KSHV pORF55 is required for Golgi localization and efficient progeny virion production.棕榈酰化 KSHV pORF55 对于高尔基体定位和有效的子代病毒粒子产生是必需的。
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A Revision of Herpes Simplex Virus Type 1 Transcription: First, Repress; Then, Express.
单纯疱疹病毒1型转录的修正：先抑制，后表达。
Microorganisms. 2024 Jan 26;12(2):262. doi: 10.3390/microorganisms12020262.
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Comprehensive Analysis of the Tegument Proteins Involved in Capsid Transport and Virion Morphogenesis of Alpha, Beta and Gamma Herpesviruses.全面分析α、β和γ疱疹病毒衣壳运输和病毒形态发生涉及的被膜蛋白。
Viruses. 2023 Oct 6;15(10):2058. doi: 10.3390/v15102058.
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A novel recombinant ORF7-siRNA delivered by flexible nano-liposomes inhibits varicella zoster virus infection.由柔性纳米脂质体递送的新型重组ORF7小干扰RNA可抑制水痘带状疱疹病毒感染。
Cell Biosci. 2023 Sep 12;13(1):167. doi: 10.1186/s13578-023-01108-1.
6
The pUL51 Tegument Protein Is Essential for Marek's Disease Virus Growth and Bears a Function That Is Critical for Pathogenesis .pUL51 衣壳蛋白对马立克氏病病毒的生长是必需的，并具有对发病机制至关重要的功能。
J Virol. 2023 May 31;97(5):e0024223. doi: 10.1128/jvi.00242-23. Epub 2023 May 8.
7
The multifaceted interactions between pathogens and host ESCRT machinery.病原体与宿主 ESCRT 机制的多方面相互作用。
PLoS Pathog. 2023 May 4;19(5):e1011344. doi: 10.1371/journal.ppat.1011344. eCollection 2023 May.
8
UL49 is an essential subunit of the viral pre-initiation complex that regulates human cytomegalovirus gene transcription.UL49是病毒前起始复合物的一个必需亚基，该复合物调节人类巨细胞病毒基因转录。
iScience. 2022 Sep 19;25(10):105168. doi: 10.1016/j.isci.2022.105168. eCollection 2022 Oct 21.
9
Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission.全面分析人类 ESCRT-III-MIT 结构域相互作用组揭示了细胞有丝分裂后期分离的新辅助因子。
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10
Insights on the cGAS-STING Signaling Pathway During Herpesvirus Infections.疱疹病毒感染期间的 cGAS-STING 信号通路的研究进展。
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