Rauzier Chloé, Chartrand Dominic J, Alméras Natalie, Lemieux Isabelle, Larose Eric, Mathieu Patrick, Pibarot Philippe, Lamarche Benoît, Rhéaume Caroline, Poirier Paul, Després Jean-Pierre, Picard Frédéric
Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ) - Université Laval, Québec, QC, Canada.
Faculté de pharmacie, Université Laval, Québec, QC, Canada.
Diabetes Metab Syndr Obes. 2024 Sep 5;17:3335-3341. doi: 10.2147/DMSO.S466051. eCollection 2024.
Optimal non-invasive biomarkers for metabolic dysfunction-associated steatotic liver disease (MASLD) remain elusive, especially in the detection of early stages. This study tested in an asymptomatic cohort of 171 men (49.2 ± 8.6 years) and 131 women (51.8 ± 8.5 years) whether waist circumference (WC) and circulating levels of insulin-like growth factor-binding protein 2 (IGFBP-2) could identify individuals with liver fat >5% as assessed by magnetic resonance spectroscopy. Participants with high WC (> 85 or 90 cm for women and men, respectively) and low IGFBP-2 (< 260 or 230 ng/mL for women and men, respectively) were characterized by a higher risk of having MASLD (46.3%, < 0.0001). Among the 68 individuals with MASLD, 73.5% fell into the subgroup with high WC and low IGFBP-2 concentrations ( < 0.0001). When combined, these markers reached a sensitivity of 73.5% and specificity of 75.2% for MASLD. Thus, WC and plasma IGFBP-2 levels might be useful as a novel, simple, and non-invasive index to support existing tools in the identification of individuals at risk of early-stage MASLD.
代谢功能障碍相关脂肪性肝病（MASLD）的最佳非侵入性生物标志物仍然难以确定，尤其是在早期阶段的检测中。本研究在一个由171名男性（49.2±8.6岁）和131名女性（51.8±8.5岁）组成的无症状队列中进行测试，以确定腰围（WC）和胰岛素样生长因子结合蛋白2（IGFBP-2）的循环水平是否能够识别出磁共振波谱评估显示肝脏脂肪>5%的个体。WC较高（女性和男性分别>85或90厘米）且IGFBP-2较低（女性和男性分别<260或230纳克/毫升）的参与者患MASLD的风险更高（46.3%，<0.0001）。在68名患有MASLD的个体中，73.5%属于WC高且IGFBP-2浓度低的亚组（<0.0001）。当联合使用时，这些标志物对MASLD的敏感性达到73.5%，特异性达到75.2%。因此，WC和血浆IGFBP-2水平可能作为一种新的、简单的非侵入性指标，辅助现有工具用于识别早期MASLD风险个体。
